Wireless mechanism for detecting an open or closed container, and methods of making and using the same

ABSTRACT

An electronic device including a continuity sensor and electrical circuitry configured to detect and report the continuity state of an article, container or product packaging is disclosed. The continuity sensor includes a first substrate with first and second coils thereon, and a second substrate with a third coil thereon. The first coil has an integrated circuit electrically connected thereto. The first substrate is part of, or is attached or secured to a part of the article, container or packaging. The second substrate is another part of, or is attached or secured to another part of the article, container or packaging. One of the article, container or packaging parts is (re)movable with respect to the other part. The first and second coils have one coupling when the article, container or packaging is closed or sealed, and a different coupling when the article, container or packaging is open or unsealed.

RELATED APPLICATIONS

This application is filed pursuant to 35 U.S.C. § 371 as a United StatesNational Phase Application of International Patent Application SerialNo. PCT/IB2017/000872 filed 19 Jun. 2017, which claims priority to U.S.Application No. 62/351,875 filed 17 Jun. 2016, and the entire contentsof each of the foregoing applications are hereby incorporated byreference.

FIELD OF THE INVENTION

The present invention generally relates to (i) product security andauthenticity and/or (ii) sensing or monitoring the state and/or use ofan article. More specifically, embodiments of the present inventionpertain to an electronic device/coil system/sensor and methods of makingand using the same, in which the electronic device/coil system/sensorincludes a plurality of coils for detecting an open or closed articlecontainer or product packaging. The present invention may also relate toa device and method for repeatedly detecting one of multiple states ormodes of an article such as a container, housing or packaging for aproduct. For example, the device and method can determine the state ofan article having a part (such as a lid or a cap) that is repeatedlymovable between first and second states (e.g., corresponding to thearticle being open or closed).

DISCUSSION OF THE BACKGROUND

Certain product security and authentication technology relies on a wirethat is torn or twisted off when the product packaging is opened.Ensuring a reliable, complete and irreversible tear can be challengingin various situations. Moreover, such technology can sense an openingevent only once.

It can be useful to detect different positions of a part of an articlethat can move repeatedly between the different states. For example,certain medicine dispensers, such as blister packs and othermulti-compartment pill or tablet dispensers, pumps, inhalation devices,etc., can be opened and closed (or raised and lowered) to obtain ordeliver a dose of medication. Detection of the different positions(which can correspond to different states or modes) of such medicinedispensers is useful for monitoring a patient's compliance and/oradherence with a medicinal therapy or regimen.

In more detail, there are instances where it is useful to detect whichstate a multi-state article is in and/or the change of state of such anarticle; by way of example, detecting when an article is in a firststate (e.g. a closed, return, reset, non-actuated, unopened or unusedstate) and/or in a second state (e.g. an open, primed, actuated or usedstate) and/or when there is a change from the first state to the secondstate and/or vice-versa. This is particularly the case where (i) achange of state results in, or is indicative of, an event occurringwhich it is desirable to monitor, and/or (ii) a correct usage of thearticle requires the article to follow a particular sequence of changeof state (e.g. for the event to occur properly or for the indicationbeing of the event occurring properly). This may be particularlyimportant where the change of state of the article is by manuallyoperation; i.e. its correct use (e.g. operation and/or time of use etc.)is user dependent, such as the case with hand-operable articles, whichmay be of the hand-held type (sized to be held in the hand, foroperation and/or use thereof).

Such detection is particularly, but not exclusively, useful formulti-use, multi-state articles; i.e. articles which are repeatedly usedand so moved repeatedly between its various states (e.g. byback-and-forth, reversible or reciprocal movement). For instance, somearticles are repeatedly moved between opened and closed states (e.g. soas to enable access to contents therein when present) or repeatedlymoved between non-actuated and actuated states (e.g. to dispense contenttherefrom or make content therein available, when the content ispresent), etc. Such state detection information can be used to form ausage history for the article; for instance: the number of times thearticle is used; the sequence of states the article is moved through toassess if the right sequence is followed for a correct usage event (orif it's a misuse event); etc. Moreover, where the article should be usedaccording to a prescribed timetable, a usage history can be used toassess compliance of the article's usage to that timetable (through theaddition of time-of-use information to the usage history).

As indicated previously, the detection of a usage history for amulti-use article may be particularly important where the change ofstate of the article is by manually operation; i.e. its correct use(e.g. operation and/or time of use etc.) is user dependent, such as inthe case with a hand-operable, multi-use article, which article may beof the hand-held type too.

Specific non-limiting examples of such multi-use, multi-state articlesare dispensers which contain, or are adapted to contain, a supply ofsomething which is to be dispensed (or made available for dispensing)over the course of a number of uses until the supply is empty (or isdeemed empty), particularly dispensers that need to be operated in a setsequence of operation steps and/or to be used with a supply of somethingwhich is to be used according to a prescribed timetable, for instance adispenser for a supply of material comprising a pharmaceutical (drug,biopharmaceutical, vaccine, or anything else containing one or moresubstances with properties for treating, preventing, palliating ordiagnosing disease in human beings (including symptomatic treatment))having a prescribed dosing regimen. Typically, such dispensers have anon-actuated state and actuated state, the movement from the former tothe latter resulting in a quantity of the supply (when present) to bedispensed or made available for dispensing. Inhalers are exemplarydispensers of this type, including pressurised metered dose inhalers(pMDI)—where the pharmaceutical is an aerosol formulation including apropellant—and dry powder inhalers (DPI)—where the pharmaceutical is indry powder form. Such types of inhalers typically have a mouthpiece andare used for delivery of a pharmaceutical to a patient's lungs (apulmonary inhaler), although it is possible to have such inhalers with adispensing outlet configured as a nasal nozzle instead of a mouthpieceso as to deliver the pharmaceutical into the patient's nose (nasalinhaler). A pulmonary inhaler typically is used with a pharmaceuticalfor treating a respiratory disease or condition (such as asthma or COPD,and usually via topical action of the pharmaceutical in the lung),although such inhalers may also be used for delivery of a pharmaceuticalfor treating a disease or condition by systemic effect via the lungs,e.g. diabetes treatment by pulmonary delivery of insulin. Nasal inhalersmay deliver a pharmaceutical for treating diseases or conditions relatedto the nose, such as rhinitis, or for systemic delivery or deliveryacross the blood-brain barrier.

As is known, such inhalers are typically hand-held and hand-operable. ApMDI typically requires the inspiratory effort of the patient at thedispensing outlet to be coordinated with the hand-operation of the pMDIso that a metered dose is dispensed into, and entrained, with theairflow through the pMDI for delivery to the pulmonary tract or nose, asapplicable. This is known as a breath-coordinated pMDI. However, toresolve the potential issue of poor user coordination, there are alsoknown breath-operated pMDIs in which the pMDI is primed and then ‘fired’when the patient inhales at the dispensing outlet.

A DPI has the same uses as described above a pMDI, but avoids the needfor a propellant which can be environmentally unfriendly through use ofa dry powder. As there is no propellant, most DPIs rely on theinspiratory effort of the patient to draw the pharmaceutical out of thedispensing outlet (breath actuation), although there are some DPIs withbreath-triggered mechanisms to assist release of the powder into theinspiratory airflow.

The dispensers of the type indicated above, including the inhalers, aretypically manually-operable (especially hand-operable), and oftenhand-held. This is also the case for the types of inhaler to bediscussed in greater detail herein.

A first type of dispenser of the kind mentioned above may include asupply in bulk form and a mechanism for dispensing or making available aportion of the bulk per actuation event. Where the supply is apharmaceutical, the mechanism will typically be a metering mechanism formetering a dose from the supply for dispensing. Examples of pulmonaryinhalers of this type are pMDIs, such as the EVOHALER pMDIs used by theGlaxoSmithKline group of companies in approved inhalation products suchas the ADVAIR/SERETIDE EVOHALER inhaler product, and reservoir-typemulti-dose DPIs (rDPIs), examples being the TURBUHALER inhaler(AstraZeneca) and the EASYHALER (Orion Corporation).

A second type of dispenser of the kind mentioned above is loaded with apre-prepared, sub-divided supply and includes a mechanism for dispensingor making available for dispensing a sub-division of the supply uponeach actuation. Typically, where the supply is a pharmaceutical it issupplied as pre-metered doses. Examples of inhalers of this type aremulti-unit-dose DPIs (mDPI) in which the pharmaceutical (in the form ofan inhalable medicament powder) is pre-metered on a carrier as discretedoses (during the manufacturing process) and then loaded in the mDPI;the mechanism is adapted in use to index the carrier to present thediscrete doses serially to an airflow path in communication with amouthpiece of the inhaler. This may also be referred to as afactory-metered mDPI. Examples of such pulmonary mDPIs are the ELLIPTAinhaler and the DISKUS/ACCUHALER inhaler (both GlaxoSmithKline), and theGYROHALER (Vectura Group PLC).

The ELLIPTA inhaler is described in detail in inter alia WO2007/012871(FIGS. 3 to 13, inclusive, and the related description) andWO2007/068896 (FIGS. 4 to 17, inclusive, and the related description),the entire contents of which are incorporated herein by reference. TheELLIPTA inhaler is used in the approved inhalation products BREO/RELVARELLIPTA, ANORO ELLIPTA, ARNUITY ELLIPTA and INCRUSE ELLIPTA marketed bythe GlaxoSmithKline group of companies.

The ELLIPTA inhaler is able to work with one or two medicament carrierstherein. When there is just a single medicament carrier in ELLIPTA, asin the ARNUITY ELLIPTA and INCRUSE ELLIPTA inhalation products, eachactuation of the inhaler results in the inhaler mechanism indexing themedicament carrier to present a metered dose on the carrier to aposition where it can be inhaled through the mouthpiece by the patient.When the ELLIPTA inhaler contains two medicament carriers, such as inthe BREO/RELVAR ELLIPTA and ANORO ELLIPTA inhalation products, eachactuation of the inhaler results in the inhaler mechanism indexing bothmedicament carriers to present a metered dose of each carrier to aposition where they are able to be inhaled simultaneously through themouthpiece by the patient. In this latter case, the metered dosedelivered to the patient is the combination of the metered doses fromeach carrier (the powder on the first carrier containing a medicamentpowder having a different active pharmaceutical ingredient (API) or APImixture than that in the medicament powder of the second carrier).

The ELLIPTA inhaler has an ‘open-inhale-close’ actuation sequence. Inother words, the ELLIPTA inhaler has a closed state (in which themouthpiece is closed by a mouthpiece cover) and an open state (in whichthe mouthpiece is no longer closed), with movement from the closed stateto the open state resulting in the inhaler mechanism indexing thecarrier(s) so that a metered dose of medicament powder is available forinhalation through the mouthpiece. Thus, it will be appreciated that itcan be useful to detect when the ELLIPTA inhaler is opened as that eventis a surrogate for a metered dose being inhaled by a patient (openingbeing a condition precedent for inhalation of a metered dose). The usehistory of the ELLIPTA inhaler can be used for monitoring the complianceof the patient with the prescribed dosing regimen for the pharmaceuticalproduct, which for the marketed products mentioned hereinabove is aonce-daily (one metered dose per 24 hour period) dosing regimen. It willbe appreciated that this logic applies generally to the use history ofany article having an open-use*-close operating sequence(*non-exhaustive examples of “use” being ready-for-use or primed (as forthe ELLIPTA inhaler) and automatic dispensing upon opening).

The opening and closing of the ELLIPTA inhaler is the patient moving theinhaler's mouthpiece cover from its closed position, in which it coversthe mouthpiece, to an open position, in which the mouthpiece is openedand mouthpiece cover caused the inhaler mechanism to index thecarrier(s) so that a metered dose is available for inhalation by thepatient. Proper usage of the ELLIPTA inhaler involves reciprocalmovement of the mouthpiece cover between its fully closed and fullyopened positions (i.e. full stroke positions). However, the inhaler canalso be operated correctly by moving the mouthpiece cover to positionsshort of these full stroke positions, due to the nature of the inhalermechanism. It would therefore be useful to detect whether or not themouthpiece cover, when opened or closed, has moved sufficiently far tothe open or closed position, as the case may be, for the inhaler to bedeemed to have been operated correctly by the patient. A misuse eventcan therefore be detected; e.g. by detecting that the mouthpiece coverhas been moved insufficiently far in one direction and/or the otherduring a use event cycle that the inhaler will not have been operatedcorrectly in that use event cycle.

This “Discussion of the Background” section is provided for backgroundinformation only. The statements in this “Discussion of the Background”are not an admission that the subject matter disclosed in this“Discussion of the Background” section constitutes prior art to thepresent disclosure, and no part of this “Discussion of the Background”section may be used as an admission that any part of this application,including this “Discussion of the Background” section, constitutes priorart to the present disclosure.

SUMMARY OF THE INVENTION

According to an aspect of the invention there is provided a multi-statearticle which comprises a sensor for sensing when the article is in atleast a first one of its states, the sensor comprising a system of coils(coil system) which is adapted to provide a coil coupling which isrepresentative of the first state when the article is in the firststate. The coil system may further be adapted to provide a coil couplingwhich is representative of a second state (different from the firststate) of the article when the article is in the second state.

According to another aspect of the invention there is provided amulti-state article which comprises a sensor for sensing when thearticle is in at least a first one of its states, the sensor comprisinga system of coils (coil system) which is able to adopt different coilconfigurations, the coil system having a first coil configuration whichis adopted when the article is in the first state and which is able toprovide a coil coupling which is representative of the first state. Thecoil system may further have a second coil configuration which isadopted when the article is in a second state (different from the firststate) of the article and which is able to provide a coil coupling whichis representative of the second state. Preferably, movement of thearticle to the first state causes the coil system to adopt (e.g. moveto) its first coil configuration; likewise, where there is the secondcoil configuration associated with the second article state, preferablymovement of the article to its second state causes the coil system toadopt (e.g. move to) the second coil configuration. In embodiments,movement of the article between its first and second states causes thecoil system configuration to move to the coil configuration whichcorresponds to the respective article state.

According to another aspect of the invention there is provided amulti-state article which comprises a sensor for sensing when thearticle is in at least a first one of its states, the sensor comprisinga near-field communication (NFC) antenna. The sensor may include asignal generator adapted to produce a signal when the article is in saidfirst state which is representative of the article being in the firststate. The signal generator may be a coil in a system of coils (coilsystem) which includes or is an NFC antenna. The sensor (or coil system)may be as otherwise described herein.

According to another aspect of the invention there is provided anarticle having a prescribed usage regime which comprises an adherencesensor for sensing article use events and storing a use event history,the sensor comprising a NFC antenna for wireless transfer of the usehistory. The sensor may be as otherwise described herein. The articlemay as otherwise described herein and/or articles to dispense a supplyof (e.g. pharmaceutical) substance having a prescribed dosing regime.

According to another aspect of the invention there is provided a methodof sensing at least a first state of a multi-state article according toother aspects of the invention comprising the steps of moving thearticle to the first state so the sensor senses the first state (e.g.produces the signal/coil coupling which is representative of the firststate). In embodiments the article is moved repeatedly back-and forth tothe first state so the sensor senses the first state at each instancethereof. In embodiments the article is moved to a second state,optionally repeatedly, so the sensor senses the second state (e.g.produces the signal/coil coupling representative of the second state).In embodiments the article is repeatedly moved back-and-forth betweenthe first and second states. In embodiments the method further comprisesthe step of storing data relating to the sensed state (e.g. coilcoupling(s)/signal) in memory on the sensor. In embodiments, the methodincludes the step of creating data relating to the time a state issensed (e.g. the time (or period of time) when the state is changed) andincluding that time data in the stored data (i.e. associating the timedata with the associated state data in the stored data). In embodimentsthe method comprises transferring (conveniently wirelessly) the storeddata to a remote computer device (e.g. a smartphone/tablet/such-like (orApp thereon)). In embodiments the data transfer is by NFC.

NFC

The NFC antenna enables wireless communication between the sensor andanother NFC-enabled article, e.g. a NFC reader, such as an NFC-enabledportable device like a smartphone, tablet or such-like. Thus, sensordata may be communicated to another NFC-enabled article. The sensor datamay be the use event history (supra) and/or (other) data stored inmemory of the sensor. The use event history may comprise stateinformation (which state has been sensed) and data representative of thetime (or period of time) of sensing of use events of the article (e.g.time of sensing of a given state). Such use event history can becompared to e.g. a prescribed usage regime.

In embodiments the sensor comprises an NFC electronic circuit.

Sensor

In embodiments the sensor is an electronic sensor, preferably at leastpart of which is printed. As an example, the coil system may be printed.

In embodiments the coils adopt a spatial arrangement with respect toeach other when the article is in its first state which is different tothe spatial arrangement adopted when the article is not in the firststate (i.e. in other article states and intermediate states). Inembodiments, the coils adopt respective first and second (different)spatial arrangements with respect to each other in the first and secondarticle states. Typically, the coils are caused to move between thefirst and second spatial arrangements by movement of the article betweenits first and second states.

In embodiments the sensor includes a movable first coil which moves withrespect to the other coil(s) as the article moves between its differentstates. Typically, the other coil(s) are in fixed positions. The movablefirst coil may be movable between first and second positions, the firstof which is the position of the movable first coil in the first state ofthe article (the second of which may be the position of the movablefirst coil in the second state). In embodiments the movement of themovable first coil between its first and second positions moves the coilsystem between the first and second spatial arrangements. In embodimentsthe coil system has second and third coils and in the first position themovable first coil is disposed adjacent to the second coil for acoupling therewith representative of the article being in the firststate. In embodiments in the second position the movable first coil isdisposed adjacent the third coil for a second coupling therewith whichis representative of the article being in the second state.

In embodiments the article comprises (a) a first structure which (i) inthe first state has a first position and in a/the second state has asecond position, and (ii) is provided with at least one coil of the coilsystem (e.g. the afore-mentioned movable first coil) of the sensor; and(b) a second structure which is provided with the rest of the coilsystem of the sensor; and the first and second structures are movablerelative to one another to move the article between its first state anda/the second state and to change the position of the least one coilrelative to the rest of the coil system to change the coupling in thecoil system (e.g. between the at least one coil and a coil of the restof the coil system) thereby to sense when the article is in its firststate and, optionally, its second state. Typically, the rest of the coilsystem on the second structure has a fixed position.

In embodiments the sensor comprises three coils, a first one of which ismovable with respect to the other two to provide (i) the coil couplingrepresentative of at least the first state, or (ii) the coil couplingsrepresentative of the first and second states, or (iii) the different(e.g. first and second) spatial arrangements for the coils. The firstcoil may be the afore-mentioned movable first coil and/or the first coilon the first structure of the article (in the latter case, the other twocoils being comprised in the coil system on the second structure). Inembodiments the coil coupling between the moving first coil and a firstone of the other coils is to sense the article being in the first stateand the coil coupling between the moving first coil and the second oneof the other coils is to sense the article being in the second state.Typically, the other two coils have fixed positions.

In embodiments the coil system comprises a driver coil, a detector coiland a moving coil (e.g. as detailed above). When the moving coil is in afirst position, corresponding to the first state of the article, thedriver coil is able to couple with the detector coil through the movingcoil to provide a coupling with the detector coil which isrepresentative of the first state. In effect, the moving coil forms acoupling bridge from the driver coil to the detector coil. Inembodiments when the moving coil is in a second position, correspondingto a/the second state of the article, the moving coil couples with thedriver coil to provide a coupling which is representative of a/thesecond state of the article. In embodiments, when the moving coil is notin the first position (i.e. the article is not in the first state) thecoupling of the driver and detector coils is different and sorepresentative that the article is not in the first state. Likewise, inembodiments, when the moving coil is not in the second position (i.e.the article is not in the second state) the coupling of the driver andmoving coils is different and so representative that the article is notin the second state. Typically, the driver and detector coils are infixed positions.

In embodiments, the driver coil is also a/the NFC antenna.

In embodiments the coil system comprises a first coil (e.g. the drivercoil supra) for producing a magnetic field (e.g. at a RF frequency orNFC protocol frequency) for inductive coupling with at least a secondcoil (e.g. the moving coil supra) of the coil system, the inductivecoupling between the coils being dependent on the state of the article;e.g. dependent on whether or not the article is in the first stateand/or dependent on the relative positioning of the coils which aredetermined by the state (and optionally also intermediate states) of thearticle.

In embodiments the second coil is movable between first and secondpositions relative to the first coil and to a third coil (e.g. thedetector coil supra) of the coil system to provide differentialinductive coupling at the third coil. As an example, in the firstposition of the second coil, corresponding to the first state of thearticle, the inductive coupling in the third coil is at a first level,and in the second position of the second coil, corresponding to a/thesecond state of the article, the inductive coupling in the third coil isat a second level which is different from (e.g. lesser than) the firstlevel. Typically, the first and third coils are in fixed positions (e.g.on the second structure of the article, supra).

In embodiments, the second coil is positioned closer to the third coilwhen in the first position than in the second position. For example, inthe first position the second coil is in close proximity to the thirdcoil (and optionally also to the first coil) and in the second positionis remote from the third coil. In embodiments, the first and secondcoils are in close proximity to one another in the first position and/orthe second position of the second coil.

In embodiments, the configuration and arrangement of the coils is suchthat the first coil is able to inductively couple with the second coilin both its first and second positions and the second coil is able toinductively couple with the third coil when in its first position, suchinductive coupling in the third coil being greater than any inductivecoupling in the third coil from the first and second coils when thesecond coil is in its second position.

In embodiments the second/moving coil in its first position is disposedbetween the first/driver coil and the third/detector coil; e.g. in abridging disposition.

In embodiments, in the second position of the second/moving coil thefirst/driver coil is positioned between the second/moving coil and thethird/detector coil.

In embodiments, when the article moves from its first state to thesecond state the first coil (also referred to as the moving coil in somestatements herein) moves closer to a first one of the other coils (thesecond coil; e.g. the third/detector coil in other statements herein)and vice-versa. Expressed another way, the first coil is movable from afirst position (corresponding to the article's first state), at whichthe first coil is at a first spacing from a first one of the other coils(the second coil), to a second position (corresponding to the article'ssecond state), at which the first coil is at a second spacing, greaterthan the first spacing, from the second coil. In embodiments, the firstcoil is proximate the second one of the other coils (the third coil;e.g. the first/driver coil in other statements herein) in both the firstand second states of the article (i.e. the first coil remains proximateto the third coil as the first coil moves during the transition ofstates of the article and/or the first coil moves between its first andsecond positions. In embodiments, the second and third coils are infixed positions (i.e. do not move with respect to each other as thearticle moves between its first and second states). In embodiments thefirst coil is positioned between (e.g. like a bridge) the second andthird coils in the first state of the article and/or first position ofthe first coil. In embodiments, in the second state of the article orthe second position of the first coil, the first coil is either notbetween (e.g. does not bridge) the second and third coils or is betweenthe second and third coils to a lesser degree than when in the firststate of the article or first position of the first coil, respectively.Typically, the second and third coils are in fixed positions.

In embodiments the sensor comprises first, second and third coils, thefirst coil is provided to a first structure of the article and thesecond and third coils are provided to a second structure of thearticle, the first and second article structures are relatively movable(e.g. by movement of one structure with respect to the other) to providefirst and second positions of the first article structure with respectto the second article structure corresponding, respectively, to thefirst and second states of the article. The coils may be as describedherein, e.g. the moving coil is on the first structure and the othercoils (e.g. driver and detector coils) are on the second structure, andthey interact as previously described when the article is in its firstand second states.

In embodiments the sensor is an electronic device which comprises amemory to store sensor data representative of the states sensed andoptionally time data associated with the state data.

In embodiments the coil system is adapted in use to produce signalsrepresentative of the state sensed. In embodiments the signals (or aprocessed form thereof) are stored in a/the memory of the sensor. Inembodiments the sensor includes an electronic circuit to process thesignals.

Article

In embodiments the first state of the article is (a) one or more of aclosed, return, reset, non-actuated, unopened or unused state or (b) oneor more of an open, primed, actuated or used state. In embodiments thefirst state is (b). In embodiments the second state is whichever of (a)and (b) the first state is not. In embodiments the first state is anopen state (optionally also an actuated state) and the second state is aclosed state (optionally also a non-actuated state), or vice-versa.

In embodiments the article is manually (hand-) operable to effect itschange of state.

In embodiments the article is a hand-held article.

In embodiments the article is a multi-use, multi-state article. Themulti-use article may be movable repeatedly between its states byback-and-forth, reversible or reciprocal movement, for instancerepeatedly movable between closed and opened states (e.g. so as toenable access to contents therein when present) or repeatedly movablebetween non-actuated and actuated states (e.g. to dispense contenttherefrom or make content therein available, when the content ispresent).

In embodiments the article is a multi-use, multi-state dispenser whichcontains or is adapted to contain a supply of something which is to bedispensed or made available for dispensing over the course of a numberof uses until the supply is empty or is deemed empty. The dispenser maybe of the type that needs to be operated in a set sequence of operationsteps and/or to be used with a supply of something which is to be usedaccording to a prescribed timetable, for instance a dispenser for asupply of material comprising a pharmaceutical having a prescribeddosing regimen. Typically, the states of a dispenser are a non-actuatedand/or closed state and an actuated and/or open state, the movement fromthe former to the latter resulting in a quantity of the supply (whenpresent) to be dispensed or made available for dispensing.

In embodiments the dispenser is an inhaler, for instance a pressurisedmetered dose inhaler (pMDI) or a dry powder inhaler (DPI), as discussedabove in the ‘Discussion of the Background’ section supra. Typically, aninhaler is hand-held and hand-operable.

In embodiments the inhaler is a multi-dose DPI, for example a reservoirDPI or a multi-unit-dose DPI (again, see the ‘Discussion of theBackground’ section supra). In embodiments the multi-dose DPI has an‘open-inhale-close’ operation sequence (a closed state in which thedispensing outlet (e.g. mouthpiece) is closed by a cover) and an openstate (in which the dispensing outlet is no longer closed), withmovement from the closed state to the open state resulting in theinhaler mechanism making a metered dose of medicament powder availablefor dispensing through the dispensing outlet. Thus, it will beappreciated that it can be useful to detect when the multi-dose DPI isopened as that event is a surrogate for a metered dose beingadministered by a patient (opening being a condition precedent foradministration of a metered dose). The use history of the multi-dose DPImay be used for monitoring the compliance of the patient with theprescribed dosing regimen for the pharmaceutical product, which forexample may be a once-daily (one metered dose per 24 hour period) dosingregimen.

It will be appreciated that the above logic applies generally to the usehistory of any article having an open-use*-close operating sequence(*non-exhaustive examples of “use” being ready-for-use or primed andautomatic dispensing upon opening). Thus, in embodiments, the articlehas an open-use-close operating sequence with the article statescorresponding to closed and open states.

In embodiments the article has an outlet and a closure (e.g. cover)therefor and the article is moved between closed and open states bymoving the closure from a closed position, in which it closes theoutlet, to an open position, in which the outlet is opened. The closuremay be moved repeatedly between its closed and open states, e.g. byreversible movement.

In embodiments the article first structure is the closure and thearticle second structure is a body of the article on which the closureis mounted for movement to change the state of the article.

In embodiments the article is an inhaler and the closure is a mouthpiececover and actuator of the inhaler.

The present invention further relates to electronic devices and methodsof manufacturing and using the same. The present invention relies onmultiple antennas that are brought in proximity to induce positivefeedback, resulting in oscillation or a change in state of a bistabledevice. The oscillation or change in state can be used to determine thestate of the device.

In one aspect, the present invention relates to an electronic device,comprising a first substrate with first and second coils thereon, and asecond substrate with a third coil thereon. The first coil has anintegrated circuit electrically connected thereto, and the firstsubstrate is a first part of an article, container or product packagingor is configured to be attached or secured to the first part of thearticle, container or product packaging. The second substrate is asecond part of the article, container or product packaging, or isconfigured to be attached or secured to the second part of the article,container or product packaging. One of the first and second parts of thearticle, container or product packaging is removable or movable withrespect to the other one of the first and second parts of the article,container or product packaging. The first and second coils have a firstcoupling when the article, container or product packaging is closed orsealed, and a second, different coupling when the article, container orproduct packaging is open or unsealed. In some embodiments, the firstsubstrate may comprise one or more parts, and the first and second coilsmay be on the same part or different parts. In either case, the firstand second coils are in fixed positions relative to each other.

In many embodiments of the electronic device, the first, second andthird coils form a continuity sensor. The continuity sensor senses ordetermines a continuity state of the container or product packaging. Insome cases, the first coupling corresponds to a closed or sealedcontinuity state, and the second coupling corresponds to an open orunsealed continuity state. Alternatively, the first coupling correspondsto the open or unsealed continuity state, and the second couplingcorresponds to the closed or sealed continuity state. In furtherembodiments, the first and second coils can have a third coupling whenthe article, container or product packaging is partially open or notfully closed or sealed. In general (but not necessarily always), thethird coupling is between the first coupling and the second coupling.

In some embodiments, one of the first and second parts of the article,container or product packaging may be removable or movable with respectto the other one of the first and second parts of the article. In afurther embodiment, the removable or movable part is repeatedly movablebetween the open and closed continuity states. For example, a repeatedlymovable part of the article, container or product packaging may be orcomprise a cap or lid connected to the article or container by a hinge,a pivot or spindle, one or more tongue-in-groove fittings, etc.

In some embodiments of the electronic device, the continuity sensorfurther comprises a transistor electrically coupled directly orindirectly with at least one of the first and second coils. In somecases, the first, second and third coils form an open loop when thecontinuity sensor has the closed or sealed continuity state, and thethird coil closes the loop when the continuity sensor has the open orunsealed continuity state. Alternatively, the first, second and thirdcoils form a closed loop when the continuity sensor has the closed orsealed continuity state, and the third coil opens the loop when thecontinuity sensor has the open or unsealed continuity state. In furtherembodiments, the closed loop propagates an oscillating signal, and theopen loop does not propagate the oscillating signal (e.g., from thefirst stationary coil to the second stationary coil).

In various embodiments, the second coil may have at least a firstcapacitor electrically connected thereto, and the third coil may have asecond capacitor electrically connected thereto. In other or furtherembodiments, the electronic device further comprises a diode or otherelement or circuit such as an envelope detector configured to detect theoscillating signal (or a maximum value thereof). The electronic device(e.g., the integrated circuit) may further comprise one or more devicesconfigured to provide a bias current at a source/drain terminal of thetransistor coupled to the first and/or second stationary coils. In somecases, the bias current may be controlled by a gain control signalcomprising a sequence of pulses having a predetermined duty cycle.

In some embodiments, the continuity sensor may have a relatively highcoupling state when the container or product packaging is closed orsealed, and a relatively low coupling state when the container orproduct packaging is open or unsealed. Alternatively, the continuitysensor may have a relatively low coupling state when the container orproduct packaging is closed or sealed, and a relatively high couplingstate when the container or product packaging is open or unsealed.

In various embodiments, the electronic device may further comprise abattery configured to provide power to the integrated circuit. In otheror further embodiments, the integrated circuit may comprise a rectifierconfigured to extract power from a wireless signal received by the firstcoil. The integrated circuit may also comprise a closed state detectorand an open state detector. Each of the closed state and open statedetectors may comprise an amplifier configured to amplify an output froma corresponding stationary coil, an envelope detector configured todetermine a maximum value of an output from the corresponding amplifier,and a latch coupled directly or indirectly to an output of the envelopedetector and configured to store the maximum value of the output fromthe corresponding amplifier.

In many embodiments, the integrated circuit comprises a printedintegrated circuit. Printing is generally a high-throughput, additivetechnology that minimizes wasteful application of materials that must besubsequently removed, and avoids the use of expensive, low-throughputequipment such as photolithography equipment.

In another aspect, the present invention relates to an article, packageor container, comprising first and second parts with an interfacetherebetween, where one of the parts is separable or movable withrespect to the other. The first substrate of the present electronicdevice is, or is on, one of the parts of the article, package orcontainer, and the second substrate is, or is on, another part (e.g.,the other one of the first and second parts) of the article, package orcontainer.

In some embodiments, the article, package or container is consideredopen when the first and second coils have the second coupling, and thepackage or container is considered closed or sealed when the first andsecond coils have the first coupling. For example, the third coil iscloser to the first coil than to the second coil when the container orpackage is closed or sealed, and when the container or product packagingis open or unsealed, the third coil is (i) absent or (ii) closer to thesecond coil than when the container or package is closed or sealed.Alternatively, the article, package or container may be consideredclosed or sealed when the first and second coils have the secondcoupling, and the package or container may be considered open when thefirst and second coils have the first coupling.

In yet another aspect, the present invention relates to a method ofdetecting a continuity state of an article, package or container,comprising placing first and second coils on a first part of thearticle, package or container, placing a third coil on a second part ofthe article, package or container, and sensing the continuity state ofthe article, package or container using the first, second and thirdcoils. One of the first and second parts of the article, container orpackage is removable or movable with respect to the other one of thefirst and second parts of the container or product packaging. The firstcoil has an integrated circuit electrically connected thereto. The firstand second coils have a first coupling when the article, package orcontainer is closed or sealed, and a second, different coupling when thearticle, package or container is open or unsealed.

In various embodiments of the method, the article, package or containeris considered open or unsealed when the first and second coils have thesecond coupling, and the article, package or container is consideredclosed or sealed when the first and second coils have the firstcoupling. Alternatively or additionally, the third coil may be closer tothe first coil than to the second coil when the article, container orpackage is closed or sealed, and the third coil is (i) absent or (ii)closer to the second coil than when the article, container or packagewhen the article, container or product packaging is open or unsealed.

As for the continuity sensor and article, package or container, thefirst, second and third coils may form a continuity sensor in thepresent method. The continuity sensor senses or determines thecontinuity state of the article, container or package. In some examples,the first coupling corresponds to a closed or sealed continuity state,and the second coupling corresponds to an open or unsealed continuitystate. In other or further examples, the first, second and third coilsmay form a loop (which may be a feedback loop) when the continuitysensor has the closed or sealed continuity state, and the third coilbreaks the loop when the continuity sensor has the open or unsealedcontinuity state. In some embodiments of the method, the loop propagatesan oscillating signal when the continuity sensor has the closed orsealed continuity state, and does not propagate the oscillating signalwhen the continuity sensor has the open or unsealed continuity state.Alternatively, the opposite arrangements are also possible (i.e., thefirst coupling corresponds to an open or unsealed continuity state, andthe second coupling corresponds to a closed or sealed continuity state;the first, second and third coils may form a loop when the continuitysensor has the open or unsealed continuity state, and the third coilbreaks the loop when the continuity sensor has the closed or sealedcontinuity state; and/or the loop propagates the oscillating signal whenthe continuity sensor has the open or unsealed continuity state, anddoes not propagate the oscillating signal when the continuity sensor hasthe closed or sealed continuity state). In one example, the methodfurther comprises detecting the oscillating signal with the open statedetector when the continuity sensor has the open or unsealed continuitystate.

Further embodiments of the method may further comprise applying a biascurrent at a source/drain terminal of a transistor coupled to the firststationary coil, controlling the bias current with a gain control signalcomprising a sequence of pulses having a predetermined duty cycle,providing power to the integrated circuit using a battery and/orreceiving a wireless signal at the first stationary coil. When themethod comprises receiving the wireless signal at the first stationarycoil, the method may further comprise extracting power from the wirelesssignal with a rectifier (which may be part of the integrated circuit).As for the present continuity sensor and article, container or package,the integrated circuit may comprise a printed integrated circuit.

It will be understood that the different aspects of the invention mayinclude embodiments based on the disclosure in the ‘Discussion of theInvention’ section, including without limitation any of the details onarticles discussed therein and/or desired aims.

The present invention further includes combinations of each aspect ofthe invention and its embodiments with part or all of the content of anyone or more of the other aspects or its embodiments, including theembodiments hereinafter to be described with reference to the Figures ofdrawings.

In the present specification the terms “article”, “device” and “product”are interchangeable except in instances where this would clearly not bethe case.

The present invention advantageously avoids any need to tear or break awire when a container or product packaging is opened to determine itscontinuity state (e.g., whether it is “opened” or “closed”), and thusavoid issues that sometimes arise with product security andauthentication technology that relies on tearing or breaking a wire. Insome embodiments, the present invention is capable of sensing multiplecontinuity states as well as sensing a continuity state times (e.g., 10or more times, 20 or more times, 30 or more times, 100 or more times,etc.) using two active (e.g., battery-powered) coils to generateelectromagnetic fields, and a passive coil passing through the twofields to provide a voltage difference. These and other advantages ofthe present invention will become readily apparent from the detaileddescription of various embodiments below.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a schematic for an exemplary 3-coil continuity sensoraccording to embodiments of the present invention.

FIGS. 2A-B are diagrams showing an exemplary design for a 3-coilcontinuity sensor according to one or more embodiments of the presentinvention.

FIGS. 3A-B are plots showing voltage on a second stationary coil of theexemplary design of FIGS. 2A-B as a function of the location of a movingcoil.

FIG. 4 is a schematic for an exemplary equivalent circuit for the 3-coilcontinuity sensor of FIGS. 2A-B.

FIG. 5 is a schematic for another exemplary 3-coil continuity sensoraccording to one or more embodiments of the present invention.

FIGS. 6A-F are views of an exemplary prototype 3-coil continuity sensoraccording to one or more embodiments of the present invention.

FIGS. 7A-F are plots showing voltage on one coil of the exemplaryprototype 3-coil continuity sensor of FIGS. 6A-F as a function of thelocation of another coil of the exemplary prototype 3-coil continuitysensor of FIGS. 6A-F.

FIG. 8 is a schematic for yet another exemplary 3-coil continuity sensoraccording to one or more embodiments of the present invention.

FIG. 9 shows an exemplary four-coil continuity sensing system accordingto one or more embodiments of the present invention, in which anauxiliary coil is added to the present three-coil system.

FIGS. 10A-B show results for the exemplary four-coil continuity sensingsystem of FIG. 9, in accordance with one or more embodiments of thepresent invention.

FIG. 11 shows an exemplary integrated circuit for use with an exemplarythree-coil continuity sensor according to one or more embodiments of thepresent invention.

FIGS. 12A-B show exemplary alternative integrated circuitry to beconnected to the first and second stationary coils of the presentcontinuity sensor according to one or more embodiments of the presentinvention.

FIGS. 13A-C show circuit diagrams of exemplary oscillators for use withand/or in the exemplary integrated circuitry connected to the presentcontinuity sensor according to one or more embodiments of the presentinvention.

FIGS. 14A-B show circuit diagrams of exemplary voltage regulatorssuitable for use with the present continuity sensors, in accordance withone or more embodiments of the present invention.

FIG. 15 shows a block diagram of exemplary closed and open statedetectors for use with the present continuity sensors, in accordancewith one or more embodiments of the present invention.

FIG. 16 shows control circuits for programming and/or writing to anonvolatile memory in accordance with one or more embodiments of thepresent invention.

FIG. 17 shows an exemplary charge pump suitable for programming thenonvolatile memory of FIG. 16 in accordance with one or more embodimentsof the present invention.

FIG. 18 shows an exemplary system including the present continuitysensor in accordance with one or more embodiments of the presentinvention.

FIG. 19 shows a diagram of another exemplary integrated circuit suitablefor use with the present continuity sensors, in accordance with one ormore embodiments of the present invention.

DETAILED DESCRIPTION

Reference will now be made in detail to various embodiments of theinvention, examples of which are illustrated in the accompanyingdrawings. While the invention will be described in conjunction with thefollowing embodiments, it will be understood that the descriptions arenot intended to limit the invention to these embodiments. On thecontrary, the invention is intended to cover alternatives, modificationsand equivalents that may be included within the spirit and scope of theinvention. Furthermore, in the following detailed description, numerousspecific details are set forth in order to provide a thoroughunderstanding of the present invention. However, it will be readilyapparent to one skilled in the art that the present invention may bepracticed without these specific details. In other instances, well-knownmethods, procedures and components have not been described in detail soas not to unnecessarily obscure aspects of the present invention.Furthermore, it should be understood that the possible permutations andcombinations described herein are not meant to limit the invention.Specifically, variations that are not inconsistent may be mixed andmatched as desired.

The technical proposal(s) of embodiments of the present invention willbe fully and clearly described in conjunction with the drawings in thefollowing embodiments. It will be understood that the descriptions arenot intended to limit the invention to these embodiments. Based on thedescribed embodiments of the present invention, other embodiments can beobtained by one skilled in the art without creative contribution and arein the scope of legal protection given to the present invention.

Furthermore, all characteristics, measures or processes disclosed inthis document, except characteristics and/or processes that are mutuallyexclusive, can be combined in any manner and in any combinationpossible. Any characteristic disclosed in the present specification,claims, Abstract and Figures can be replaced by other equivalentcharacteristics or characteristics with similar objectives, purposesand/or functions, unless specified otherwise.

In the various drawings, use of like reference numerals indicates likefeatures, but the use of dissimilar reference numerals does notnecessarily indicate dissimilar features.

For the sake of convenience and simplicity, the terms “part,” “portion,”and “region” are, in general, interchangeable and may be usedinterchangeably herein, but are generally given their art-recognizedmeanings. Wherever one such term is used, it also encompasses the otherterms. In addition, the terms “antenna” and “coil”, are usedinterchangeably, and where one term is used, it may also encompass theother term, but these terms are also generally given theirart-recognized meanings. Also, unless indicated otherwise from thecontext of its use herein, the terms “known,” “fixed,” “given,”“certain” and “predetermined” may be used interchangeably and generallyrefer to a value, quantity, parameter, constraint, condition, state,process, procedure, method, practice, or combination thereof that is, intheory, variable, but is typically set in advance and not variedthereafter when in use.

The present invention advantageously enables electrical devices todetect or determine the continuity state of a container or package(which may be a multi-use container or package) without any need to tearor break a wire. However, in some embodiments, the present invention canbe used in conjunction with a product authenticity sensor (e.g., basedon OpenSense™ technology commercially available from Thin FilmElectronics ASA, Oslo, Norway) that includes a wire crossing aninterface of the product packaging. A further option is the use of sucha wire on a tab, the pulling/tearing of which breaks the wire anddisconnects a “battery off” switch or battery disable circuit to savebattery power until the product is actually used. Furthermore, thepresent invention allows use of conventional, relatively simple circuitelements, relatively simple electrical and/or electromagnetic phenomena,and conventional processing, thereby minimizing the cost ofmanufacturing and/or the development time for certain tags (e.g.,wireless devices and/or “smart” labels) including the present electricaldevices.

The present invention concerns an electronic device including acontinuity sensor that wirelessly senses the continuity state of acontainer or product packaging. The device relies on two antennas orcoils on a first part of the container or product packaging and a thirdcoil on a second, separable first part of the container or productpackaging. The third coil couples the two antennas or coils on the firstpart of the container or product packaging (e.g., when the container orproduct packaging is in one of a plurality of different states). In atypical embodiment, the two antennas or coils on the first part of thecontainer or product packaging have relatively low coupling in theabsence of the third antenna/coil or when the container or productpackaging is in a different state. Thus, the two antennas or coils onthe first part of the container or product packaging are broughttogether (e.g., by inductive coupling) to induce positive feedbackresulting in an oscillation or change in state of the electronic device,which in one or more embodiments is a bistable device (e.g., a devicehaving two stable states, such as the “open” and “closed” continuitystates). The oscillation or change in state can be detected to determinethe change of state in the electronic device (e.g., an RF or NFC tag),and hence, the change in the state of the article (e.g., from closed toopen). The positive feedback can be generated by either electric ormagnetic coupling.

One application of the present invention to product security and/orauthentication involves a radio frequency (RF), near field communication(NFC) or other tag (e.g., a device that communicates using a wirelessprotocol such as Bluetooth and/or a predetermined frequency in the HF,VHF, UHF or RF band) on product packaging, in which two coils are placedon one part or component of the packaging, and the other coil is placedon another, separable part or component of the packaging. When the partor component of the product packaging containing the third coil isremoved or separated, coupling between the remaining coils increases ordecreases significantly (depending on the position of the third coilrelative to the first two coils), which can be detected and used as asignal.

Another application of the present invention is directed towardsdetection of the continuity state of a multiple-use product or article,involving the radio frequency (RF), near field communication (NFC) orother tag on the product or article, in which two coils are placed onone part or component of product or article, and the other coil isplaced on another, separable or separately movable part or component ofthe product or article. When the part or component of the product orarticle containing the third coil is moved relative to the two coils, asignal from one or both of the remaining coils changes significantly.

The present invention relies on multiple antennas/coils (typicallythree) to sense a continuity state (e.g., “open” or “closed”) of acontainer or packaging containing a product (e.g., an authenticproduct). One of the antennas/coils moves, or changes its positionrelative to the other two antennas/coils, the positions of whichgenerally remain fixed. The moving antenna/coil works in conjunctionwith the two fixed antennas. In a first continuity state 1 (e.g.,“closed”), magnetic coupling between the fixed coils is small. However,in a second continuity state 2 (e.g., “open”), magnetic coupling betweenthe fixed coils is increased due to the presence of the moving coil.Alternatively, this can work in the complementary way (i.e., in thefirst continuity state, magnetic coupling between the fixed coils ishigh due to the presence of the moving coil, and in the secondcontinuity state, the magnetic coupling between the fixed coils isrelatively small). This property may be used to construct continuitysensors that do not require physical connection (e.g., a wire) and thatcan be used and possibly re-used any number of times. Moreover, it maybe possible to determine intermediate states between the first andsecond continuity states (e.g., to quantify the degree ofcontainer/package openness or security/continuity, to identify a“partially open” state, etc.).

The technique can be extended to the use of electric coupling instead ofmagnetic coupling.

FIG. 1 shows a continuity sensing system 100 that illustrates the basicprinciple behind the invention. The exemplary continuity sensing system100 includes first and second stationary coils (e.g., red and greencoils 102 and 104) and a third coil (blue coil 106) that changesposition (e.g., that moves from one position proximate to the first coil102, but relatively distant from the second coil 104, to anotherposition closer to the second coil 104, but in which the center of thethird coil 106 is relatively distant from the first coil 102). Theproximity of the third coil 106 (e.g., the moving coil) increasescoupling between the first and second coils 102 and 104 (e.g., thestationary coils). In absence of the third coil 106, coupling betweenthe first and second coils 102 and 104 is low by design.

Continuity sensing generally refers to a capability and/or function thatsenses or determines whether an article, a container or productpackaging is open (or, in the case of product authenticity and/orsecurity, has been tampered with) on the one hand, or is closed (e.g.,in the case of product authenticity and/or security, in itsfactory-sealed condition) on the other hand. Continuity sensing alsoincludes in some cases determining whether the article, container orproduct packaging is partially open or has one or more of a plurality ofparts or compartments that are open and one or more parts orcompartments that are closed.

When determining the continuity state of the container or productpackaging (e.g., when the electronic device is in an “open/closed”detection mode), none of the coils 102, 104 or 106 needs to receive asignal from a reader (assuming the electronic device in a tag on thecontainer or product packaging is powered by an internal power source,such as an integrated or external battery). However, the first coil 102,and optionally the third coil 106 and/or the second coil 104, canparticipate in communicating information to the reader. Thus, the coils102, 104 or 106 may have a dual role; that is, the same coils thatenable open/closed state detection (e.g., that are in the continuitysensor) can also participate in NFC or other wireless communications.The open terminals on the first and second coils 102 and 104 areconnected to other elements and/or components completing a circuit.

FIG. 2A shows a system 200 designed to demonstrate the feasibility of acontinuity sensor based on one or more principles of the continuitysensing system 100 in FIG. 1. A third coil 210 on a first substrate 220was placed in a first position in proximity to a first coil 230 on asecond substrate 240. A second coil 250 was also on the second substrate240. The first and second substrates 220 and 240 can be a label (e.g., aflexible plastic film that further includes an adhesive and that mayfurther include graphics and/or one or more layers of paper and/ormetallization), a backing sheet for electronics, etc. Alternatively, thefirst, second and third coils can be formed on and/or embedded in theproduct container/housing itself, and thus not on a separate substrate(e.g., the container may be the substrate for the first and second coils230 and 250 and/or the third coil 210). Furthermore, the coils 210, 230and 250 may be printed on the first and second substrates 220 and 240.

In various embodiments, the first coil 230, which can be involved inwireless signal reception/transmission, has an integrated circuit (IC;not shown, but which may be a printed IC on the same or a separatesubstrate, which may be a flexible substrate, such as a product label)coupled or electrically connected to it through the bonding pads 232 andone or more capacitors electrically connected to it and/or the ICthrough the bonding pads 232 and/or 234. Furthermore, the second coil250 and the third coil 210 (which are generally not involved in wirelesssignal reception/transmission) may have one or more capacitorselectrically connected to them through the bonding pads 252 and/or 212.The capacitor(s) connected to the second coil 250 may be part of aprinted IC (PIC) that is generally (but not necessarily) separate fromthe printed IC coupled or electrically connected to the first coil 230.The capacitor(s) and/or PIC connected to the second coil 250 may be onthe same or a separate substrate (which may be a flexible substrate,such as a product label) as the second coil 250. Alternatively, thecapacitor connected to the second coil 250 may be an externalcomponent(s). The capacitor(s) connected to the third coil 210 areseparate (e.g., an external component) because the third coil 210 isphysically removed from the part of the container or product packagingon which the first and second coils 230 and 250 are located (e.g., the“main body” of a product container) or is otherwise physically relocatedrelative to the first and second coils 230 and 250. The capacitor(s)connected to the third coil 210 can be a standard part, implemented as aPIC or implemented as part of the third coil. In each case, thecapacitor(s) coupled to the respective coil generally have a capacitanceand/or other parameter values adapted to facilitate or enable resonanceof the coil(s).

The third coil 210 was made to resonate at approximately 14 MHz, and anexcitation was applied at the first coil 230. The voltage at the secondcoil 250 was monitored. FIG. 3A is a graph showing the voltage on thesecond coil 250, which was about 0.56 V (by simulation) at the resonantfrequency.

FIG. 2B shows the system 200 in which the third coil 210 is in a second,different position with respect to the red and green coils 230 and 250(which remain in the same positions with respect to each other). Thesecond position of the third coil 210 corresponds to a torn or openedproduct package or container. In the second position of the third coil210, the first coil 230 is more strongly coupled to the second coil 250.As shown in the graph of FIG. 3B, the voltage on the second coil 250 wasabout 3.07 V (by simulation) when the third coil 210 was in the positionshown in FIG. 2B, between 5 and 6 times the voltage on the second coil250 when the third coil 210 is in the low-coupling state (e.g., as shownin FIG. 2A). Thus, the states of the bistable continuity sensor 200 canbe characterized as a “high-coupling state” and a “low-coupling state.”

In various embodiments of the invention, the high-coupling andlow-coupling states of the system 200 correspond to different states(for example, different continuity states such as closed and open) of acontainer or product packaging with which the system 200 is associated(for example, by attachment to or incorporation in the product containeror housing). In some embodiments, at least one component of the system200 (e.g., part of the product container or packaging) is able to moverepeatedly between different states as described above (e.g.,back-and-forth), and consequently, can be associated with a product thathas a feature that can be repeatedly movable between different states orpositions so as to detect such changes of product state. Over time, ahistory of the product states can be compiled. This is particularlyuseful for determining compliance with a medical therapy or treatmentregimen when the product is a medicine delivery article or system.

FIG. 4 shows an equivalent circuit 300 for the system shown in FIGS. 1and 2A-B. The equivalent circuit 300 includes a three-port circuitelement 310, a first path to the first coil comprising a resistor 320and a capacitor 322, a second path to the second coil comprising acapacitor 330 and a resistor 332, and a third path that includes or isto the third coil comprising a capacitor 340. The resistor 320 may havea resistance that is higher than (e.g., by 2-5×) the resistance of theresistor 332. The capacitor 322 may have a capacitance that is higherthan (e.g., by 2-3×) the capacitance of the capacitor 340, and thecapacitor 330 may have a capacitance that is higher than (e.g., by 3-4×)the capacitance of the capacitor 322. The three-port circuit element 310is not necessarily a physical circuit element, but rather, may be arepresentation of a circuit element that couples the different coils toeach other inductively and/or capacitively.

Experimental verification of the feasibility of a 3-coil continuitysensor was further performed using a 3-coil system 400 as shown in FIG.5. The position of the third coil 410 changes from a first positioncorresponding to a “closed” state to a second position corresponding toan “open” state. The fixed first and second coils 420 and 430,respectively, are shown in association with matching capacitors 422,424, 432 and 434 for impedance matching and are resonant nominally atthe same frequency. The moving third coil 410 is made resonant with asingle capacitor 412 nominally at the same frequency.

When the movable coil 410 is in a first position or locationcorresponding to a closed continuity state, the gain between port 1 and2 (|s21|) is small. When the movable coil 410 is in a second position orlocation corresponding to an open continuity state, |s21| is appreciable(e.g., significantly larger than in the first position or location), andthere is a phase shift (e.g., of 180° or about 180°) close to theresonant peak. Therefore, it is possible to utilize this property toconstruct a continuity detector or sensor, or to measure an amount ordegree of packaging/container continuity.

FIGS. 6A-F show various positions of the third coil 410 of the coilsystem 400 as it changes from a first position corresponding to a“closed” state in FIG. 6A to a second position corresponding to a fully“open” state in FIG. 6F. The third coil 410 is a movable coil, whereasthe first coil 420 and the second coil 430 have fixed positions withrespect to each other. The first, second and third coils 410, 420 and430 are shown as concentric rings or loops, but in practice, theycomprise a spiral, with a gap in each ring or loop and an electricalconnection between adjacent rings or loops.

An excitation was applied at the first coil 420 when the third coil 410in each of the positions shown in FIGS. 6A-F, measurements of thevoltage on the second coil 430 were taken (using a conventionalvoltmeter), and plots of the voltage on the second coil 430 when thethird coil 410 was in each of the positions shown in FIGS. 6A-F areshown in the corresponding FIGS. 7A-F. Thus, FIGS. 6A-F and 7A-F show orrepresent the signal level of a tag having 3 coils arranged as describedherein as a function of the position of a cover (e.g., a hinged cover,on which the third coil 410 is placed or secured). In one example, thethird coil 410 may be printed on a label that is secured to the coverusing an adhesive.

The signal on the second coil 430 in FIG. 7F (corresponding to the fully“open” state of the coils in FIG. 6F) is about 4 times greater than thesignal on the second coil 430 in FIG. 7A (corresponding to the “closed”state of the coils in FIG. 6A). Furthermore, the signal on the secondcoil 430 in FIG. 7D (corresponding to the position of the third coil 410in FIG. 6D) is about 2 times greater than the signal on the second coil430 in FIG. 7A. An increase in signal strength of 2× relative to the“closed” state (optionally, for at least a predetermined minimum lengthof time) may indicate or correspond to an “open” or “partially open”state, depending on the configuration and/or parameters of thecontinuity sensor (e.g., the gain of the electronic device or continuitysensor when a continuity loop therein oscillates, which must be lessthan the signal strength difference between “open” and “closed” states;see, e.g., the discussion of FIG. 8 below). The voltage on the secondcoil 430 corresponds directly to the strength of a wireless signaltransmitted or broadcast by the first coil 420 and/or the extent towhich the third coil 410 couples the first coil 420 to the second coil430.

The example of FIGS. 6A-E is a relatively simple example, to verify thatthe concept behind the present invention is feasible. For example, thelocations and/or geometries of the coils are not particularly limitedand may be further optimized and/or shaped for a particular application(e.g., to conform to the product, container or packaging to which itwill be applied to or into which it will be incorporated) without undueexperimentation. Although a comparison of the two plots in the photos ofFIGS. 7A-F show an increase of about 4× in FIG. 7F for the high-couplingstate, increases in signal strength for the high-coupling (or, in thisexample, “opened”) state of >5× relative to a low-coupling (or, in thisexample, “closed”) state have been experimentally demonstrated. Thelower plot (shown by itself in FIG. 7A) shows weak coupling(corresponding to the “closed” state shown in FIG. 6A, in which thethird coil 410 is relatively far away from the second coil 430). Theupper plots (especially in FIGS. 7D-F) show strong coupling, as thethird coil 410 moves closer to the second coil 430. Furthermore,electrical coupling (as a dual or alternative of magnetic coupling) maybe applied to, and may be more suitable for, certain situations and/orembodiments.

Non-limiting examples of articles (e.g., containers or productpackaging) that have one stationary part and another part that isrepeatedly movable between a first state (e.g., an open state) and asecond state (e.g., a closed state) include dispensers (for example,medicine dispensers such as inhalation devices, and bottles or jars withpump dispensers), bottles or jars with caps (which may be hinged orotherwise fastened or secured to the bottle or jar), containers withhinged or sliding lids, boxes with hinged flaps such as regular slottedcontainers, etc.

Furthermore, as shown by the relationship between the positioning of thecoils in FIGS. 6A-F and the voltages induced on the coil 430 as shown inFIGS. 7A-F, accurate sensing and/or counting can be performed as afunction of the position of the passive coil 410 (e.g., the percentageof the distance between a first position corresponding to a fully closedstate and a fully open state, or in the case of the passive coil 410traversing an arcuate path, the angle of the passive coil 410 relativeto the fully closed state or fully open state). For example, the“closed” state may correspond to 0-30% of the distance between the firstand second positions, a “partially open” state may correspond to >30%and <80% of the distance between the first and second positions, and an“open” state may correspond to 80% or more of the distance between thefirst and second positions. However, the thresholds between thedifferent continuity states can vary in different examples. The “closed”state may correspond to from 0-5% to 0-60% of the distance between thefirst and second positions, the “open” state may correspond to from 50%or more to 95% or more of the distance between the first and secondpositions, and the “partially open” or “partially closed” state may bethe range of distances between the “closed” and “open” states, as longas none of the distance ranges overlap. Alternatively, the thresholdsbetween different continuity states can be defined by the voltageinduced on the second coil 430. For example, the “closed” state maycorrespond to a voltage of 1-1.5 times the voltage on the second coilwhen the passive coil is in the first position, a “partially open” statemay correspond to 1.5-3 times the voltage on the second coil when thepassive coil is in the first position, and an “open” state maycorrespond to greater than 3 times the voltage on the second coil whenthe passive coil is in the first position. Often, one or moreinflections are apparent in the curve or plot of the voltage on thesecond coil as a function of the position of the passive coil, and suchinflections can provide useful thresholds for determining differentcontinuity states. The numbers given in these examples are exemplary,and the invention is not limited to these examples in any way.

FIGS. 6A to 6F will now be further described to focus on the article 481in accordance with the invention shown therein which includes theabove-described coil system 400 in accordance with the invention. Itwill be understood, in place of the coil system 400, this embodiment canwithout limitation also use an electronic device/coil system/sensor forstate detection according to any of the embodiments described hereinwith reference to FIG. 1, FIGS. 2 to 4, FIG. 8, FIGS. 9 and 10, FIG. 11,FIG. 12 and FIG. 18 or any of those embodiments (including the specificembodiment of FIGS. 5, 6 and 7) as modified by any of (i) thedisclosures made with reference to FIGS. 13 to 17 and 19, and/or (ii)the other disclosures herein, including in the ‘Summary of theInvention’ section and the claims.

In this embodiment, the coil system 400 is mounted to one of the outersides 483 of the article 481 (for convenience only, termed the “frontside”). The mounting of the coil system 400 to the front side 483 may bethrough substrates (not shown, but see the description of FIG. 2), whichcarry the coil system 400 and which are adhered to the external surfacepresented by the article's front side 483.

The article 481 in this non-limiting embodiment is the hand-held,hand-operable, breath-actuated ELLIPTA pulmonary mDPI (hereinafter the“inhaler”) referred to hereinabove in the ‘Discussion of the Background’section. The inhaler 481 has a mouthpiece 485 on which a user placestheir lips to inhale a metered dose of the medicament powder(s) in theinhaler 481. The inhaler 481 further has a mouthpiece cover 487 whichhas a closed position (shown in FIG. 6A) in which the cover 487completely covers the mouthpiece 485. This defines the closed state ofthe inhaler 481 in which the inhaler should be kept when not in use,thereby preventing foreign objects, for example particulates, such adust, entering the mouthpiece 485.

As shown by the sequence of FIGS. 6A to 6F, the mouthpiece cover 487 isrotatable from the closed position to an open position (shown in FIG.6F). This movement is reversible to return the mouthpiece cover 487 fromthe open position to the closed position and, moreover, thisback-and-forth rotation of the cover between its closed and openpositions can be repeated over-and-over.

The open position of the mouthpiece cover 487 represents the open oractuated state of the inhaler 481. As described in greater detail in theInternational patent applications concerning the inhaler and mentionedin the ‘Discussion of the Background’ section, movement of themouthpiece cover 487 from its closed position to it open positionactuates the inhaler 481 by causing a metered dose of the medicamentpowder(s) inside the inhaler 481 to be presented at an internal airflowpath in communication with the mouthpiece 485 so that a patient canthereafter inhale the dose. After the patient has inhaled the dose, themouthpiece cover 487 is rotated back to the closed position. So, theinhaler 481 has an ‘open-inhale-close’ handling characteristic.

From the foregoing it will be understood that the mouthpiece cover 487is a hand-operable actuation member of the inhaler 481. In more detail,the mouthpiece cover 487 is of an ‘n’-shape (or saddle-shape) form inside view and comprises a cover section 487 a at one end, which coversthe mouthpiece 485 in the closed position and which a patients gripswith one hand to move the mouthpiece cover 487, and a pair ofspaced-apart arms (one 487 b of which is partially visible in FIGS. 6Bto 6F) which extend away from opposite sides of the cover section 487 ato be located to the respective opposite front 483 and back (not shown)sides of the inhaler 481. These arms 487 b connect the mouthpiece cover487 to the body 489 of the inhaler 481 (which comprises inter alia themouthpiece 485 and, therewithin, the medicament powder(s)) to a point(hidden from view) in the body 489 about which the mouthpiece cover 487is reversibly rotatable between its closed and open positions.

In more detail, one of the arms 487 b drivably connects to a rotatablecomponent (ratchet—not shown) of the internal mechanism (a complex gearmechanism—not shown) of the inhaler 481 (which internal mechanism islocated inside the body 489). The rotation of the mouthpiece cover 487is about the axis of rotation of the ratchet and drives rotation of theratchet therewith.

To move the inhaler 481 between its closed and open states, the patient(or other user) typically will grip the cover section 487 a of themouthpiece cover 487 in one hand and the body 489 in the other hand andthen use their hands or fingers thereof to rotate the mouthpiece cover487 relative to the body 489.

The effect of each return cycle of movement of the mouthpiece cover 487(starting from the closed position) to the open position is aunidirectional, incremental advancement of the internal mechanism (by aratcheting effect). The incremental advancement of the internalmechanism occurs on the opening part of the cycle, which advancement ofthe internal mechanism indexes the next dose of medicament powder(s) tothe airflow path in communication with the mouthpiece 485 (unless nodoses are left or present). On the closing part of the cycle, theratchet is reset ready for the next cycle.

A subtlety of the opening part of the cycle of the mouthpiece cover 487is that there is no drive from the mouthpiece cover to the internalmechanism in the initial phase of the opening movement of the mouthpiececover 487 from its closed position, as is described in detail inWO2007/012871. This ‘lost-motion’ occurs until the mouthpiece cover 487has moved to a position (see FIG. 6B) in which the mouthpiece 485 ispartially opened, whereupon the drive from the mouthpiece cover 487 tothe internal mechanism engages (the rotating ratchet engages a ratchetgear) and stays engaged for the rest of the opening movement of themouthpiece cover to the open position (i.e. from the mouthpiece coverposition of FIG. 6B to its fully open position in FIG. 6F). Thelost-motion allows for intentional partial opening of the mouthpiececover 487 for cleaning of the mouthpiece 485, as well asinadvertent/intentional play of the mouthpiece cover 487 when in itsclosed position, between successive inhaler uses, without resulting inindexing or partial indexing of a new dose of the medicament powder(s).

The unidirectional, incremental advancement of the internal mechanismcaused by each opening of the mouthpiece cover 487 also results in adose counter, visible through a window on the front side 483 of theinhaler body 489 (not shown), to be decremented until the end of thedose count. The dose count indicates the number of doses of themedicament powder(s) remaining in the inhaler.

As can be seen from FIGS. 6A to 6F, the coil system 400 is mounted tothe front side 483 of the inhaler 481 such that the coil 410 is on themouthpiece cover 487 and that the coils 420, 430 (which may be referredto as a driver coil and a detector coil) are on the inhaler body 489 infixed positions. In this way, the coil system 400 is able to detectwhich state (closed or open/actuated) the inhaler is in by detectingwhether the mouthpiece cover 487 is in its closed or open position.

Based on the operation of the ELLIPTA inhaler, the coil system 400 canform a compliance (or adherence) monitor for the inhaler 481 inasmuch asthe detection of the open state of the inhaler is a surrogate for a dosebeing delivered to a patient; i.e. if the inhaler has been moved fromits closed state to its open state, by moving the mouthpiece cover 487from its closed position to its open position, this indicates that themetered dose indexed to the airflow path will be inhaled by a userbefore the inhaler 481 is (re)closed.

As will be known, a patient will need to take a metered dose of themedicament powder(s) in the inhaler 481 according to a prescribed dosingregimen, for instance once-a-day. Thus, compliance (or adherence) of apatient to that prescribed dosing regimen may be assessed by comparingthe prescribed dosing interval (e.g. 24 hours for once-daily-dosing) tothe periods of elapsed time between each opening event of the inhaler481 detected by the coil system 400. Clearly, such complianceinformation will be useful to observe relationships between clinicaloutcomes with compliance behaviour, both in clinical trials andreal-world settings.

As mentioned in the ‘Discussion of the Background’ section, while theproper use of the ELLIPTA inhaler 481 is movement of the mouthpiececover 487 between its full stroke positions (FIG. 6A and FIG. 6F), itwill work correctly if the mouthpiece cover 487 moves back-and-forth toat least predetermined positions short of these full stroke positions.So, for instance, for the inhaler 481 to be closed properly themouthpiece cover 487 has to be closed sufficiently far enough for theratchet to reset (e.g. corresponding to the mouthpiece cover positionshown in FIG. 6B), otherwise the subsequent opening event will not indexthe next metered dose. For the inhaler 481 to be opened correctly, themouthpiece cover 487 has to be opened from a closed position, i.e.closed fully or to at least the predetermined position indicated above,to a point sufficiently far that the indexing makes the next metereddose of powder(s) available for inhalation (e.g. corresponding to themouthpiece cover position shown in FIG. 6E).

The coil system 400 may therefore be arranged to detect the full strokepositions (or very close approximations thereto) so that anything lessthan full opening or full closing represents a misuse of the inhaler.Alternatively, the coil system 400 may be arranged to detect open andclosed states as based on the mouthpiece cover being moved to at leastthe predetermined positions when moving in the opening or closingdirection. A misuse event can therefore be detected by the coil system400 as the mouthpiece cover not been moved sufficiently far in onedirection and/or the other during a use event cycle for the inhaler 481to have been operated correctly. Another potential alternative is forthe coil system 400 to detect and discriminate both positions for extradata on the usage (proper vs acceptable); e.g. for training purposes.

Consequently, the coil system 400 can also provide information not juston whether the ELLIPTA inhaler has been used, which can be used forcompliance monitoring, but also on whether such use is proper/acceptableor not.

So, in the context of the invention an article's state means that thearticle is in that state on an absolute basis (like the fullyopen/closed state of the inhaler 481) and/or is deemed to be in thatstate (like the inhaler 481 being deemed in its open or closed states ifthe mouthpiece cover 487 has moved to at least predeterminedopening/closing positions). In the latter instance, what is deemed to bethe state of concern (i.e. to be sensed) will depend on the article atissue, but this is well within the normal practice of the skilled personin the art.

While in the above-described inhaler the coil system 400 is mounted tothe external surface of the inhaler front side 483, it may be mounted tothe external surface of the opposite rear side of the inhaler (notshown). Further alternatively, embodiments can be envisioned in whichthe coil system 400 is mounted to an inner surface of the inhaler 481.In addition, a variety of different means can be envisioned for theinhaler 481 to carry the coil system 400, such as having the coil system400 integrated into the inhaler 481, as for example by embedding intothe inhaler's physical structure (e.g. by integrating into the physicalstructure of the mouthpiece cover 487 and the body 489).

The above-described inhaler embodiment establishes that the inventionhas utility for articles of the type having a plurality of (e.g. two ormore) different states (e.g. open and closed; actuated/primed/operatedand rest/return; etc.) to detect one, more or all of those states thearticle is in. Such utility is present for a single-use article (e.g.open or actuate only once), but more especially for a reusable ormulti-use article (e.g. one that is repeatedly openable or actuatable bymoving (e.g. reversibly or reciprocally) between its different states).

Of course, the invention has a particular utility for those articleswhose usage it is desirable to monitor or detect, such as articles witha prescribed usage regimen. As an example, mention may be made ofhealthcare products which have a prescribed usage or dosing regime,including pharmaceutical dispensers (injectors, inhalers, etc.) fordispensing a pharmaceutical to a prescribed dosing regimen.

As with the inhaler 481 described above, such articles will typically bemoved from one state to another through the relative movement of twoarticle structures between different positions, for instance by relativemovement of two article parts (e.g. a closure (cover or cap), on the onehand, and a body, on the other hand). The coil system 400 may then bearranged so that the coil 410 is located on one structure and the coils420, 430 are located on the other structure (e.g. in fixed positions)such that the respective positions of the coils in the differentrelative positions of those structures results in differentiable coilcoupling of the coils 420, 430 with the coil 410 for detection of thedifferent states. Of course, the other types of electronic devices/coilsystems/sensors disclosed herein may be similarly arranged on sucharticles to the same effect.

FIG. 8 shows another equivalent circuit for an exemplary continuitysensor in accordance with one or more embodiments of the presentinvention. The above-described properties of the three-coil system canbe used to induce positive feedback resulting in oscillation. In oneembodiment, the combination of three coils (e.g., the first, third andsecond coils) is placed in the feedback path of an amplifier to induceoscillations.

Gain control in the transistor Q1 is achieved by changing a bias currentat the gate of the transistor Q1, which is controlled by the amount ofcoupling of an excitation at the first coil 520 to the second coil 530,and/or by applying a bias current to a source/drain terminal of thetransistor Q. The bias current (e.g., source/drain current) is underopen loop control, which is advantageous for embodiments in which thesensor and IC are powered by a battery, as open loop control (e.g.,without use of feedback) conserves battery power when the high-couplingstate is maintained for a relatively long period of time, and helps withNFC and possibly other wireless communications while the sensor is inthe high-coupling state. By default, the gain of the transistor Q1 isset to a low enough value that current drain is small. This isparticularly advantageous in embodiments in which the tag/electronicdevice is powered by a battery, rather than by extraction of power froma received wireless (e.g., RF or NFC) signal (which is the case in somealternative embodiments). Also, in one or more embodiments, the LoadModulation switch is off.

In a weak coupling scenario, there may not be enough loop gain in thetransistor Q1 to overcome losses in the coils 510, 530 and 550 andinduce oscillations (e.g., in a loop comprising the first, third andsecond coils 510, 530 and 550 and the transistor Q1). For example, whenthe third coil 510 is absent or far away (e.g., from the second coil550), losses in the coils 510, 530 and 550 increase or are relativelyhigh, which can bring the loop gain to below unity (e.g., <1). In thiscondition, oscillations may not occur. However, when the third coil 510is in a position to introduce strong coupling, the loop gain can exceedunity, and the loop phase shift is 0° (e.g., since the first, third andsecond coils 510, 530 and 550 introduce a 180° phase shift nearresonance, as does the transistor Q1, resulting in a total phase shiftof 0° in the loop). The oscillations, which occur when the continuitystate of a container or product packaging on which the electronic deviceis attached or secured is a high-coupling state, generate a DC voltageat the output A of the diode 560. The amplitude of the oscillations(e.g., the amount of coupling) determines the magnitude of the DCvoltage at output A of the diode 560.

The electrical device 500 may be used for wireless (e.g., NFC or RF)read operations. The antenna(s) 510, 520 and 530 as described above areused to sense the presence of an NFC signal from a handheld device (suchas an NFC-enabled smart phone) and communicate back to the handhelddevice. In presence of an NFC field, a finite voltage gets generated atthe output A of the diode 560 even in the “closed” (e.g., weak coupling)state (i.e., where there is no oscillation). However, the diode 560detects the oscillations when the voltage at output A has a durationthat exceeds a predetermined threshold (e.g., a duration that is longeror significantly longer than that caused by NFC or other wirelessinterrogation). However, there may be other components and/or ways todetect the oscillation, so the invention is not limited to use of adiode to do so. The load modulation switch may be activated when thevoltage at the diode output A exceeds a threshold voltage.

Thus, the voltage at the diode output A representing the continuitystate of a container or product packaging on which the electronic deviceis attached or secured can be differentiated by observing, monitoringand/or measuring the duration of the voltage at the diode output A.Other techniques for differentiating between the continuity sensoroutput and the wireless (e.g., RF or NFC) field include amplitudemodulation (e.g., detection of a signal having a different amplitude),frequency modulation (e.g., detection of a signal having a differentfrequency), switching (e.g., the diode output A, which may be connectedto an NFC communication circuit under normal operation, may beperiodically disconnected from the NFC communication circuit andtemporarily connected to the sensor while the first [red] coil 510 isbeing driven), and relative measurement (e.g., detecting the rising edgethat occurs when the first [red] coil 510 is initially driven). Whereasthe NFC interrogation may be few seconds at most, the “open” state ofthe container or product packaging generally lasts longer than the NFCinterrogation (e.g., frequently for at least tens of seconds, and insome cases, permanently). Usually, the occurrence of an NFCinterrogation and the opening of the container or product packaging donot occur simultaneously, and are thus assumed to be separate ormutually exclusive events.

If the handheld device is brought in proximity to the electronic deviceand/or continuity sensor during the time that oscillation occurs in thecoil-transistor loop due to an “open” continuity state, there will be acollision between electromagnetic signals (e.g., in the coil-transistorloop), and the NFC interrogation will fail. To mitigate this scenario(and conserve battery power in embodiments including a battery), thegain control signal is not a DC signal, but rather, a sequence of pulseshaving a predetermined duty-cycle. The duty cycle (e.g., 50% on, 50% offin each cycle) provides time intervals when the oscillation in the loopstops. During these intervals, an NFC interrogation can succeed.

In an alternative embodiment, the above-described properties of thethree-coil system can be used to induce positive feedback resulting in achange in state of the bistable electronic device. In addition, thepresent continuity sensor can work in a complementary fashion (i.e., theclosed state may correspond to relatively strong coupling and arelatively strong signal [i.e., a “high-coupling state”], and the “open”state may correspond to relatively weak coupling and a relatively a weaksignal [i.e., a “low-coupling state”]). However, in oscillation-basedembodiments of the electronic device that include a battery, such acomplementary continuity sensor may cause a constant current drain fromthe battery. Thus, the complementary continuity sensor may be moresuitable for a bistable sensors in electronic devices that extract powerfrom a received wireless signal (e.g., in which one coil/antenna iscoupled to an integrated circuit that includes a rectifier).

FIG. 9 shows an exemplary four-coil continuity sensing system 600according to one or more embodiments of the present invention, in whichan auxiliary (or compensation) coil 640 is added to a three-coil systemcomprising moving coil 610 and stationary coils 620 and 630. Each of themoving coil 610 and stationary coils 620 and 630 includes first andsecond terminals 612 a-b, 622 a-b and 632 a-b, respectively, configuredfor electrical attachment (directly or indirectly) to an IC (not shown).The coils 610, 620 and 630 are connected to an IC and/or discretecomponent (such as a capacitor) through bond pads 616, 626 and 636,respectively. The second (outer) terminals 612 b, 622 b and 632 b areelectrically connected to one of the bond pads 616, 626 and 636 (otherthan the first terminal 612 a, 622 a and 632 a) by a strap 614, 624 and634, respectively. Typically, the straps 614, 624 and 634 are isolatedfrom the coils 610, 620 and 630 by an insulation layer, which maycomprise a plastic, a glass, a ceramic or other electrical insulator.The bond pads 616, 626 and 636 other than those connected to a coil 610,620 or 630 may be connected to traces that electrically connect one ormore other components, such as a battery, an external sensor, one ormore resistors and/or capacitors, a display, etc. to the IC. The firstterminals 612 a, 622 a and 632 a and the bond pads connected to thesecond terminals 612 b, 622 b and 632 b may also be connected to one ormore traces that electrically connect another component to the IC.

The auxiliary loop 640 is configured to reduce a low residual couplingthat may be present between the second stationary coil 630 and the firststationary coil 620, and may further compensate for the impedance of thesecond stationary coil 630. The auxiliary loop 640 may have dimensionsand/or a number of loops sufficient to provide a predetermined ordesired amount of impedance compensation. The auxiliary loop 640 isconnected to the second stationary coil 630 by a first trace 645 a andto an IC (not shown) by a second trace 645 b, a terminal 642, and astrap 644 (which is isolated from the first and second traces 645 a-b byan insulator, as described herein). In the absence of the auxiliary coil640, there may be some unintentional coupling between the first andsecond stationary coils 420 and 430. The unintentional coupling tends toreduce the sensitivity (e.g., of the first and second stationary coils420 and 430) to the presence of the moving coil 410, and the moving coil410 has to first overcome any unintentional coupling to create asignificant change in the second stationary coil 430. The auxiliary loop640 may reduce this unintentional coupling, and consequently enhancesensitivity of the system to the presence of the moving coil 410 as itapproaches the second stationary coil 430.

FIG. 10A is a graph showing the correlation between experiment andsimulation for detection of a closed state in an example of the presentcontinuity sensor containing the 3-coil system 410, 420 and 430 and theauxiliary coil 640 in FIG. 9, secured to a product container having acap or lid that opens angularly (i.e., by pivoting on a spindle, rod orother connection between the cap/lid and the body of the container),such as the ELLIPTA inhaler shown in FIGS. 6A to 6F. The plotted datashow the impedance (in ohms) of the first stationary coil 420 as afunction of the angle of the moving coil 410 relative to the firststationary coil 420. The effect of the auxiliary coil 640 is alwayspresent.

FIG. 10B shows the gain between port 1 and port 2 (see, e.g., FIG. 5)for open-state detection of the same system as that for which the testresults in FIG. 10A were obtained. FIG. 10B shows increased coupling(e.g., between the first and second stationary coils 420 and 430) as afunction of the angle of the moving coil 410 relative to the firststationary coil 420. The effect of the auxiliary coil 640 is alwayspresent.

There is no change in permeability as the angle of the moving coil 410relative to the first stationary coil 420 changes, or duringclosed-state vs. open-state detection. No ferro- or ferrimagneticmaterial is present. In the open state, the moving coil 410 couples anoscillating signal from the first stationary coil 420 to the secondstationary coil 430, resulting in a signal on the second stationary coil430 sufficiently strong to generate an “open state” flag. During theclosed state, the moving coil 410 loads the first stationary coil 420sufficiently to reduce the effective impedance seen by a transistorproviding a bias to the output of the first stationary coil 420 (e.g.,transistor 742 in FIG. 11), resulting in a reduced RF voltage at thedrain of the transistor. This way, the sensitivity to the angle (ordistance) variation between the moving coil 410 and the first stationarycoil 420 around the thresholds for detecting the closed and open statescan be achieved.

The use of an auxiliary coil is not limited to the particular embodimentherein described, but may be deployed in other embodiments as will beunderstood by the skilled person in the art.

FIG. 11 shows an exemplary integrated circuit (IC) 700 for use inconjunction with a further example of the present 3-coil continuitydetector 500′. Similar to the continuity detector 500 in FIG. 8, thecontinuity detector 500′ includes a first moving coil 510, a firstcapacitor 512 connected to a terminal of the first coil 510, a second“closed state” coil 520, a second capacitor 522 (which may be part ofthe integrated circuit 700) connected to a terminal of second coil 520,a third “open state” coil 530, and third and fourth capacitors 532 and534 connected to a terminal of the third coil 530. The first coil 510moves between the position shown, which corresponds in this example toan open state of the container or packaging, and a position rotatedcounterclockwise from about 60° to about 120° (and in one example,about) 90-100°, corresponding to a closed state of the container orpackaging. Alternatively, the first coil 510 may moves between theposition shown and a position parallel or substantially parallel withthe second coil 520.

The IC 700 includes a first continuity state detector and closed statelogic 710, load modulation logic 720, an RF oscillator 730, a biascircuit 740, and an amplifier, second continuity state detector and openstate logic 750. The first continuity state detector and closed statelogic 710 receives an output signal from the second coil 520, an outputsignal from a load modulation switch 712, and a periodic (e.g., clock)signal from a digitally-controlled oscillator (DCO; not shown). A bias745 is also applied to the first continuity state detector and closedstate logic 710 by the bias circuit 740 and a transistor 742. Theperiodic signal from the DCO is also received by the RF oscillator 730and the amplifier, second continuity state detector and open state logic750.

During operation of the IC 700, the transistor 742 is biased insaturation mode by the DCO, the output of which is received by the biascircuit 740. The DCO may also be a low power oscillator (LPO).Otherwise, the transistor 742 is turned off by the DCO. The signaloutput signal from the second coil 520 (biased by the bias circuit 740and transistor 742), is modulated (e.g., has its amplitude reduced) whenthe load modulation switch 712 is closed. The load modulation switch 712is closed and opened by the output of the load modulation logic 720.

In the closed state, the first coil 510 is rotated towards the secondcoil 520, and the signal output from the second coil 520 is relativelyhigh. Thus, the detector and logic in the first continuity statedetector and closed state logic 710 may comprise a threshold detectorthat outputs an active “closed state” flag 715. In addition, the firstcontinuity state detector and closed state logic 710 may output a signal(“Vdd for Wireless TX”) to wireless communication circuitry, such as amodulator (see, e.g., FIG. 19), for wireless transmission to an externalreceiver. The signal may comprise a power supply or a data signal, andthe wireless communication circuitry may output an amplitude-modulatedsignal.

In the open state, the first coil 510 couples the signal from the secondcoil 520 to the third coil 530, resulting in an output signal 535 havingsufficient strength to generate an “open state” flag from the amplifier,second continuity state detector and open state logic 750. During theclosed state, the first coil 510 loads the second coil 520 sufficientlyto reduce the effective impedance seen by transistor 742, resulting in areduced RF voltage at the drain of transistor 742. This creates the“closed state” flag 715. In this manner, the continuity sensor 500 mayhave increased sensitivity to variations in the angle between the firstcoil 510 and the second and/or third coils 520 and/or 530 around thethresholds for the closed and open states (and, when there is a gapbetween the thresholds for the closed and open states with no overlapbetween the closed and open states, the thresholds for a “partiallyclosed” or “partially open” state between the closed and open states).

In some embodiments, each of the stationary coils is associated with anindependent integrated circuit (IC). For example, a first IC iselectrically connected to the first stationary coil, and a separatesecond IC is electrically connected to the second. stationary coil. Eachof the first and second ICs may be a printed IC (PIC). In the example ofFIG. 11, the first IC is electrically connected to the second coil 520,and the second IC is electrically connected to the third coil 530.

Generally, the first and second ICs may include an oscillator (e.g., alow power oscillator), an open or closed state sensor and/or detector,and a controller (a microcontroller or control logic circuit). One orboth of the first and second ICs may include a memory (e.g., anon-volatile or one-time programmable [OTP] memory comprising aplurality of memory cells or elements) and a memory write (orprogramming) circuit. The first and second ICs may have the same or adifferent configuration.

In further embodiments, the second IC (connected to the secondstationary coil 530) may include a real-time sensor or timer circuit, amemory and a controller configured to (i) record the time at which thedevice was opened and (ii) determine if a sample of the product wastaken or the device was actually used each time that the container orpackage was opened. In one example, the controller determines if asample was taken or the device was used through an app (e.g., on aprogrammed NFC reader, such as a smart phone) that reads the memory (orthe part thereof) that stores the continuity sensor output (e.g., usingan NFC protocol).

FIGS. 12A-B show an alternative solution for the integrated circuitry tobe connected to the first and second stationary coils. FIG. 12A shows afirst printed IC (PIC) 800, and FIG. 12B shows a second PIC 900. One orboth of the first and second PICs 800 and 900 may be manufactured byprinting a doped polysilane (PDPS) ink to form semiconducting featuresor structures in the PIC.

Referring to FIG. 12A, PIC 800 contains open and closed statesensor/detector blocks 810 and 820, a main controller 830, a low poweroscillator 840 configured to help the controller 830 manage power andcount time slots (e.g., points in time when the container or package isopened), and a wireless (e.g., NFC) modulator 860. The MCU 830 can alsocontrol memory read and write operations and frame or information packetgeneration. The controller 830 also interfaces with a controller on thesecond PIC 900, which manages write and read operations of all memories,dynamically generates error codes (e.g., cyclic redundancy check [CRC]code), assembles the frame or information packet to be transmittedwirelessly, and serially transmit the frame or information packet to theNFC modulator 860 in the first PIC 800, which then communicateswirelessly with the reader (not shown).

The first PIC 800 may perform any of a number of tasks. For example, thefirst PIC 800 may assist the first stationary (“red”) coil to performits role in the three-antenna sensor system (e.g., system 400 in FIG. 5or system 500 in FIG. 8) and communicate wirelessly with a scannerand/or reader. A crystal oscillator 850 on the first PIC 800 mayenergize the first stationary coil (or antenna) during the “closedstate” detection mode or process, and can provide a link from thewireless reader to the sensor system using a wireless protocol in thememory read mode (e.g., during a memory read operation).

During closed state detection, the degree or extent of coupling betweenthe first stationary coil and the moving (“blue”) coil or antennachanges the load impedance of the amplifier 812 receiving the output ofthe first stationary coil that is amplified by the amplifier 812 anddetected by the closed state envelope detector 814. This is shown in theclosed state detector block/module 810. Similarly, during open statedetection, the degree or extent of coupling between the first stationarycoil and second stationary (“green”) coil or antenna via the moving coilis amplified by the amplifier 822 receiving the output of the secondstationary coil and detected by the open state envelope detector 824.This is shown in the open state detector block/module 820. The amplifiergains are directly proportional to the respective impedances, and thepeak voltage swings are detected by the respective closed and open stateenvelope detectors 814 and 824. The DC voltages from the envelopedetectors 814 and 824 are compared against one or more pre-set referenceby the slicers 816 and 826, respectively, to generate the signal outputby the slicers 816 and 826.

The first PIC 800 may read an incoming wireless (e.g., NFC) frame fromthe second PIC 900. For example, the memory 922 (FIG. 12B) may store anintended or prescribed usage pattern (e.g., a drug dose delivery regimenor schedule). When a memory read operation is initiated by a wirelessreader such as a smartphone, the read mode is detected, and the MCU 830signals the auxiliary controller 910 on the second PIC 900 to read thememory 922. Error checking code (e.g., CRC) is added to the data fromthe memory 922 by error code block 934, and the serial data from thesecond PIC 900 is then encoded and modulated by the encoding module 936(e.g., as per an NFC protocol). The encoding module 936 may also encodeand modulate the serial data from the second PIC 900 according to asecond wireless protocol, such as a “tags-talk-first” (TTF) protocol.

The first PIC 800 may include the main controller 830 for the overallcontinuity sensing system, and may interface with the auxiliarycontroller 910 of the second PIC 900. The first PIC 800 may providepower management for the continuity sensing system using a low poweroscillator 840 to power various blocks during different cycles oroperations. The first PIC 800 may also perform a time keeping functionby providing one or more timing signals (e.g., a real-time signal, witha frequency of, e.g., 1 Hz) to the second PIC 900, which manages (e.g.,records and reads out) time slots using the memory write module 924, thememory 922, and the memory read circuitry 932.

The parameters of the low power oscillator 840 may be determined fromthe capacity of the battery (not shown) after self-discharge, thestandby leakage current for the entire continuity sensing system, thepower consumption when the continuity sensing system is active, theduration of time during which the continuity sensing system is in astandby state and is active (e.g., for an expected period of use, suchas one month, 60 days, 90 days, 1 year, etc.), and the duty cycle (e.g.,the ratio of active operation time to standby time).

In various embodiments, the oscillator variation over temperature,battery drop (e.g., output voltage decrease over time) and aging iswithin 1.0% or less (e.g., within 0.6%, 0.4%, etc.) to minimize orcontrol a total error (e.g., in the real-time clock function). When theoperating frequency is below a certain threshold, trimming theoscillator (e.g., coupling the oscillator signal or a bias to theoscillator with one or more resistors and/or capacitors) to a relativelyhigh accuracy (e.g., 0.25%) may be challenging and may consume more areathan is desired. Operating the oscillator 840 at a higher frequency(e.g., above the certain threshold) reduces the challenge of trimmingand facilitates generating a duty cycle appropriate for power cycling(for example, when the time of active operation is in a range of 0.1-100ms and the oscillator frequency is in a range of 0.1-1000 Hz [e.g., 1Hz]). However, operating the oscillator 840 at a higher frequency mayincrease the dynamic power consumption.

FIG. 13A shows a circuit diagram of a relatively simple two-inverter RCoscillator 840-A suitable for use as the low power oscillator 840 in theIC 800 of FIG. 12A. The RC oscillator 840-A includes a first inverterinv1, a second inverter inv2, a capacitor C in series with the first andsecond inverters inv1 and inv2, and a resistor R connected to (i) thenode V1 between the first and second inverters inv1 and inv2 and (ii) anode Vi (e.g., the input to the first inverter inv1 and/or a terminal orelectrode of the capacitor C). The other terminal or electrode of thecapacitor C is connected to the output V2 of the second inverter inv2.

The two-inverter RC oscillator 840-A can generate a periodic signal witha relatively low frequency (e.g., in the range of 0.1 Hz-1.0 kHz) usingthe resistor R and the capacitor C. The period (i.e., the reciprocal ofthe frequency) of the oscillator 840-A can be calculated according toEquation [1]:

$\begin{matrix}{{{Oscillator}\mspace{14mu}{Period}} = {{{{RC} \cdot \ln}\frac{V_{T} + V_{DD}}{V_{T}}} + {{{RC} \cdot \ln}\frac{V_{T} - {2V_{DD}}}{V_{T} - V_{DD}}}}} & \lbrack 1\rbrack\end{matrix}$where V_(DD) is power supply voltage to the oscillator, V_(T) is thethreshold voltage at which the inverters inv1 and inv2 switch outputstates, R is the resistance of resistor R, and C is the capacitance ofcapacitor C.

The frequency of the oscillator 840-A is directly proportional to R andC. The reduce power consumption and generate a periodic signal having arelatively low frequency (e.g., on the order of 0.1-10 Hz) using theoscillator 840-A, the resistor R and the capacitor C may be external tothe integrated circuit 800 (FIG. 12A) to create a large time constant.Placing the resistor R and the capacitor C on the substrate or die ofthe integrated circuit 800 may cause the integrated circuit 800 to havea larger area than desired (e.g., for the dimensions and/or aestheticsof the product packaging). The accuracy of the oscillator 840-A may becontrolled by the tolerances of the resistor R and the capacitor C,which may be less challenging when they are external to the integratedcircuit 800. The frequency of the oscillator 840-A is dependent on theratio V_(T)/V_(DD), which may be trimmed in the integrated circuit 800.This ratio changes as a function of supply voltage (i.e., V_(DD)), asthe switching threshold of the inverters inv1 and inv2 does not scale orchange with changes in V_(DD). To trim the frequency of the oscillator840-A, a capacitor bank may be included in parallel with the capacitorC, and one or more of the capacitors in the capacitor bank may beincluded in the circuit 840-A (e.g., using one or more switchesconnected to the capacitors in the capacitor bank) to produce aparticular and/or desired frequency at a particular supply voltage.

A possible disadvantage of the oscillator 840-A is that its charging anddischarging currents may vary with the supply voltage. Accordingly, theoscillator 840-A may consume greater power as the supply voltageincreases. External resistor and capacitor components may also make theoscillator 840-A relatively susceptible to electrostatic discharge (ESD)damage.

As the battery voltage drops, the frequency of the oscillator 840 (FIG.12A) is affected. The frequency variation of the oscillator 840 can bemitigated by operating the oscillator at a fixed voltage that staysrelatively constant as the battery drops, and can be controlled byregulating its supply voltage using a voltage regulator (e.g., alow-power, low-drop out regulator). The voltage regulator may provide arelatively constant DC voltage output (optionally at predeterminedmaximum load current, for example of 1-100 μA). A conventional low-powerreference voltage generator (which may receive a supply voltage from thebattery) may be external to the IC 800.

FIG. 14A shows a circuit diagram of a single-stage, low-dropoutregulator 1000 that generates a relatively constant, fixed voltage atnode V_(OUT) as the battery drops. The regulator 1000 comprises afixed-current operational amplifier (OP-AMP) 1010 in a feedback loop1020 that controls a p-channel transistor 1030. The regulator 1000 isconfigured to regulate a predetermined output voltage (V_(OUT)) of,e.g., 1.5-3.3V. The output V_(OUT) of the regulator 1000 decreaseslogarithmically with increasing DC load current. However, in anembodiment configured to regulated to an output voltage of 2.5V, theoutput V_(OUT) of the regulator 1000 was within ±0.1V over a DC loadcurrent from 10% of the maximum load current to the maximum loadcurrent.

Power consumption by the regulator 1000 may be reduced or minimized bykeeping the bandwidth of the regulator 1000 relatively low (<100 kHz,<10 kHz, <1 kHz, etc.). Signals with relatively fast transitionsgenerally require a relatively high bandwidth response. The currents forsuch fast-transitioning signals may be provided by an external loadcapacitor (not shown). A possible disadvantage of the regulator 1000 isthat it may consume power (e.g., continuously) during its operation.

An alternative regulator 1050 (e.g., a single-stage, adaptive biasing oradaptive-biased low-dropout regulator) is shown in FIG. 14B. Theadaptive biasing alters the tail current of the error amplifier(transistor M_(p)) in accordance with the load current (e.g., I_(f)). asa result, the regulator 1050 achieves better regulation thanfixed-biased, single-stage topologies. One advantage of the regulator1050 over multiple-stage low-dropout regulators is that the regulationloop (e.g., output V_(o) controlling the gate of transistor M₃) can beeasily compensated. The regulator 1050 is configured to regulate anoutput voltage V_(o) of 1.0-3.0V, with maximum DC load current of 5-20μA.

FIG. 13B shows a circuit diagram of an alternative oscillator (e.g., anI-C oscillator) 840-B. The circuit includes a start-up block 842, acurrent reference block 844, a charge/discharge sensing block 846, and aclock generation block 848. For low-power operating currents, theoscillator 840-B is configured to operate alternately as a currentsource and as a current sink in the sub-threshold region. The currentreference block 844 may be trimmed (e.g., for offsets caused by processvariations) using a trimming resistor R_trimming, which controls thepower consumption of the oscillator 840-B and which may be internal tothe IC 800. A capacitor C_trimming, which may be external to the IC 800and which may be in parallel with an internal capacitor array, iselectrically connected to the sensing node V_(C) to trim the frequencyof the oscillator 840-B. The reference current (I4-I5) charges the nodeV_(C). When V_(C) is above the threshold voltage of transistor M1, theoutput of the inverters INV shuts off the reference current to thecapacitor C_trimming. At this point, the voltage V_(C) is discharged bythe sink current source I5. The frequency of the oscillator 840-B can becalculated according to Equation [2]:

$\begin{matrix}{{Frequency} = \frac{V_{R}}{{2{RC}\;\Delta\; V_{C}}\;}} & \lbrack 2\rbrack\end{matrix}$where R is the resistance of the resistor R_trimming, C is thecapacitance of the capacitor C_trimming, and ΔV_(C) is thecharging/discharging voltage across the capacitor C_trimming.

The frequency of the oscillator 840-B is directly proportional to theresistance R and the capacitance C. It may be important to select and/ormanufacture resistor and capacitor components with tight tolerances tomeet any requirements for high accuracy of the oscillator 840-B. Thefrequency of the oscillator 840-B is also dependent on ΔV_(C), which maybe trimmed on chip and/or off-chip. The frequency of the oscillator840-B is typically independent of the supply voltage (e.g., to a firstorder), which may reduce or eliminate the benefit(s) of a low-dropoutregulator. The power consumption of the oscillator 840-B is alsogenerally independent of the supply voltage. One disadvantage of theoscillator 840-B may be that the voltage swing on the charging anddischarging node V_(C) is relatively small, which can result in a lowsignal-to-noise ratio. Also, if an external capacitor is used in thecapacitor C_trimming, it may be somewhat prone to ESD.

A further alternative low-power oscillator (e.g., a multi-stagecurrent-controlled ring oscillator) 840-C is shown in FIG. 13C. Thecurrent-controlled ring oscillator may have any odd number of stages 845a-x greater than or equal to 3. The bias current I_(D4) to the inverters(e.g., M2 and M3) is controlled by a bias or voltage generator that maybe external to the chip 800.

The input voltage V_(inVCO) to the transistor M5 controls the biascurrent I_(D4) to the inverters. The bias current I_(D4) to theinverters limits the charging and discharging currents, which in turnmakes the power consumption of the oscillator 840-C independent of thesupply voltage (e.g., VDD). The frequency of the ring oscillator 840-Cmay be calculated according to Equation [3]:

$\begin{matrix}{f_{osc} = \frac{I_{D}}{{NV}_{DD}C_{TOT}}} & \lbrack 3\rbrack\end{matrix}$where N is the number of stages, VDD is the supply voltage, and C_(TOT)is the total capacitance at the output of each inverter. One possibledisadvantage of the oscillator 840-C is that the frequency is dependenton the supply voltage VDD, as shown in Equation [3]. The oscillator840-C may also benefit from a voltage regulator (e.g., to provide VDDand/or V_(inVCO)). One advantage of the oscillator 840-C is that itscomponents can be included completely in the IC 800.

FIG. 15 shows a block diagram of exemplary components for exemplaryclosed and open state detectors 810 and 820, similar or identical tothose shown in FIG. 12A. The closed and open detectors 810 and 820 mayshare some circuit elements, although the invention is not limitedthereto.

In the path of the closed state detector 810, the output of a crystaloscillator 880 is amplified by an amplifier 850. A tank capacitor 855receives the amplified crystal oscillator signal, and the output of thetank capacitor 855 is converted to a multi-bit digital signal with adigital-to-analog converter (DAC) 890. The DAC 890 may have a resolutionof at least 2 bits (e.g., 3 to 10 bits), but can be relatively simple(e.g., on the order of 5 bits). Thus, the crystal oscillator 880effectively drives the amplifier 812 for the first stationary coil 420in the closed state detector 810 with a constant amplitude (e.g., and ata predetermined frequency, such as 13.56 MHz). This process isunaffected by any coupling between the first stationary coil 420 and anyother coil.

Thus, the present continuity sensing system may comprise a standardPierce oscillator. The amplifier 850 may have the highest gain possiblethat does not saturate the output of the amplifier 812. This may beachieved by adjusting level(s) of the bias to the amplifier 812, whichallows the amplifier 812 to successfully detect a closed state (e.g.,when the impedance of the tank capacitor 855 changes due to couplingchanges in the coils 410, 420 and/or 430). As a result, the amplifier850 may have a minimum and/or maximum output voltage of 0.8-3.3V (e.g.,1.0 to 2.5 V) at a predetermined frequency (e.g., 13.56 MHz). The gainof the amplifier 850 may be at least 4 times (or, alternatively, atleast a minimum increase, such as greater than 8, 10 or 12 dB) when thephase of the periodic signal from the crystal oscillator 880 crosses 0,a measure of positive feedback and oscillatory behavior.

The first stationary coil 420 is a load for the amplifier 812. Thedistance of the moving coil 410 from the first stationary coil 420changes the coupling between these coils. A change in coupling betweenthe moving coil 410 and the first stationary coil 420 results indifferent reflected impedances seen by the amplifier 812. The gain ofthe amplifier 812 is directly proportional to this impedance. The outputvoltage swing of the amplifier 812 is a function of the distance orangle between the moving coil 410 and the first stationary coil 420.

The output of the amplifier 812 in the closed state detector 810 iscapacitively coupled to a second digital-to-analog converter 813. Thedigital signal from the second digital-to-analog converter 813 isreceived by an envelope detector 814 that detects the peak of thedigital signal, and the resulting DC voltage is compared against areference voltage (e.g., from a third DAC 817) in a comparator 818 togenerate the final closed/not closed state output. The closed/not closedstate output is stored in a latch 819 (e.g., for output as a closedstate signal or flag).

The open state detector 820 works on a transmission mode principle,where the strength of the signal transmitted from the first stationarycoil 420 to the second stationary coil 430 via the moving coil 410varies as a function of the distance between the moving coil 410 and thesecond stationary coil 430. Based on the distance between the movingcoil 410 and the second stationary coil 430, the strength of thereceived signal at the second stationary coil 430 varies. The tankamplifier 822 for the second stationary coil 430 and the circuit blocksdownstream therefrom may be configured to provide gain to signals havingan amplitude greater than a certain or predetermined threshold.

The threshold for signals to be amplified by the amplifier 822 may bealigned to the distance or angle between the moving coil 410 and thesecond stationary coil 430. Thus, as the second stationary coil 430 coiland the moving coil 410 couple more strongly, the output signal startsto toggle. The presence of a toggling signal indicates an open state. Astatic high or low signal indicates a not open state.

The amplifier 812 for the first stationary coil 420 may be important tothe performance of both the closed and open detectors 810 and 820. Theamplifier 812 may be biased to keep it from saturating, so thatinformation about the closed state and the “not closed” state can bedetected. A saturated amplifier output may be unable to distinguishbetween the two states.

The amplifier 812 may consumes the most power of all of the circuitblocks in FIG. 15, and power management of the amplifier 812 may bebeneficial to prolonging the life of the battery. Amplifier gain dependson its bias current. A large and stable gain under varying operatingconditions (e.g., load impedances) provides a wide detection window.Detection of closed and open states relies on a changing impedance ofthe load on the capacitor 855 and/or the capacitor 815 as the couplingbetween the first stationary coil 420 and the moving coil 410 changes.

The output of the amplifier 812 is converted to a DC value (e.g., by theDAC 813) for input to the envelope detector 814. At particularfrequencies (e.g., 13.56 MHz), the output of the amplifier 812 mayinclude some ripple. The envelope detector 814 may comprise a diode anda capacitor. The impedance of the diode and the capacitor in theenvelope detector 814 may control the transient performance of theenvelope detector 814.

The input to the envelope detector 814 may be trimmed (e.g., by the DAC813, which may have a resolution of from 3 to 7 bits) and compared to apre-set reference (e.g., the output of a relatively high-resolution DAC817, which may have a resolution of from 6 to 12 bits) by a comparator818. The comparator 818 may comprise a high-gain amplifier that sensesthe DC voltage output from the envelope detector 814. The comparator 818uses the reference signal from the DAC 817 to “slice” between closed andnot closed states.

The ripple on the DC voltage from the amplifier 812 may reduce themargin available to the comparator 818 for detection of the closedstate. This ripple is inversely proportional to the RC value (e.g., ofthe amplifier 812 and/or circuitry between it and the crystal oscillator880). To reduce this ripple and improve detection margin, the rippleshould be relatively small.

The time during which the closed state and open state detectors 810 and820 are active (e.g., turned on) may be as small as possible to reducecurrent consumption and improve battery life. The active mode time ofthe closed state and open state detectors 810 and 820 may be, forexample, from 1 to 50 ms, or any value or range of values therein.

However, if the detector 810 is turned on for a short interval, then theoutput of the envelope detector 814 may not be fully developed, and thestate detection could be erroneous. On the other hand, if the detector810 is turned on for a longer duration, the detection accuracy isbetter. Since the envelope detector 810 may consume a relatively largeamount of current, the envelope detector 814 turn-on time is a tradeoffbetween accuracy and battery life. Simulations of the accuracy of theenvelope detector 814 as a function of time help to determine an optimalactive mode time for the state detector 810 (which is included in theabove active mode time range).

The amplifier 822 for the second stationary coil 430 is configured toconvert input signals corresponding to an open state into an outputsignal that can be detected. The output signal is periodic in accordancewith the coupling frequency and is ideally a square wave. The amplifier822 for the second stationary coil 430 amplifies an open state signal,but rejects (does not amplify) a “not open” state signal, from aprevious stage (not shown, but which detects the open vs. not openstates, and which may comprise a comparator similar to comparator 818 inthe closed state detector 810). The amplifier 822 may comprise multiplegain stages. The output waveform (e.g., at 13.56 MHz) from the amplifier822 may be divided down in frequency by divide-by-n circuit 825 for easeof evaluation and measurement.

A multiplexer 870 (FIG. 12A) may select for output on or through thefirst stationary antenna 420 (i) an output of the open state detector820 or the closed state detector 810, or (ii) the wireless (e.g., NFC)communication modulator 860 to a reader (e.g., a smart phone). Inabsence of the wireless communication field, the open state detector 820and the closed state detector 810 are typically activated at or after afixed time interval (e.g., every second, every 15 seconds, every minute,every hour, every day, etc.) to check the continuity state of thepackage or container. Logic in the IC (e.g., IC 800 of FIG. 12A) candetermine the presence of an external wireless frequency source, andshuts off or deactivates the open state/closed state detectors 810/820upon detecting this frequency of radiation. The multiplexer 870 (whichmay comprise a plurality of low on-impedance switches) may be configuredto switch or enable the first stationary antenna 410 (e.g., FIG. 15)only to communication wirelessly at this time or in this state. The maincontroller 830 of the IC 800 may activate the second IC 900 and receivea data stream from the second IC 900. The data stream from the second IC900 (which may comprise a data frame or data packet) is transmitted tothe reader by the first IC 800 via the first stationary coil 410 using aconventional wireless communication (e.g., the Tag Talks First, or TTF)protocol. The data may be encoded using a convention encoding scheme(such as On-Off keying and/or Manchester encoding) before transmission.

A block diagram for the second IC 900 is shown in FIG. 12B. The secondIC 900 has three power domains. An auxiliary control unit 910 is in thebattery power domain, a memory write module 924 (which may comprise aplurality of memory write circuits) and the memory 922 are in a“Battery++” power domain, and the memory read circuits 932 and thewireless communication data processing logic 934 and 936 are in the VDDdomain 930.

The second IC 900 may provide any of a number of functions. For example,the second IC 900 may manage and/or process time slot information (asdescribed herein) alone or together with the first IC 800. The second IC900 may write data to the memory 922 when an event (e.g., a change inthe continuity state of the package or container) is detected. Thesecond IC 900 may read different memory elements (e.g., in response todifferent memory addresses being provided to the auxiliary control 910)and assemble a wireless data frame or packet. In some embodiments, thefirst IC 800 initiates a memory read operation. The second IC 900 mayalso read a memory space or address that stores unique ID information,and assembles a correctly sequenced data stream e.g., a data frame) fortransmission to the first IC 800. The second IC 900 may dynamically(e.g., in real time) determine error correction code (e.g., the CRCcode) when a read operation is initiated. The second IC 900 may alsocalculate and/or update the CRC as product usage data (e.g., acumulative number of open and closed states) is recorded in the memory922. The second IC 900 may output a data package for wirelesscommunication in a serial format to the first IC 800 for encoding and/ormodulation, or may perform either or both of the encoding and modulationfunctions itself. The second IC 900 may synchronize its operations withthose of the controller 830 in the first IC 800 to keep the overallsystem synchronized.

In some embodiments, a memory read operation is initiated (e.g., by themain controller 830) when a reader is in the vicinity (e.g., within 3-10meters, 3-10 cm, etc.) of the first stationary coil 410 (e.g., FIGS. 5,8, and 15). The memory read operation can be initiated even if thebattery is depleted or discharged. When the reader energizes the firstIC 800 (e.g., by power extraction using the first stationary coil 410and a rectifier coupled thereto), the main controller 830 may generateand transmit to the second IC 900 (i) a supply voltage sufficiently highfor at least the memory 922, the memory read circuits 932, and the dataprocessing circuits 934 and 936 to perform the memory read functions and(ii) a periodic (e.g., clock) signal for the memory read functions. Oncethe supply voltage and periodic signal are received by the second IC900, the second IC 900 initiates a memory read operation (e.g.,according to a standard wireless communication protocol). The datapackage (or payload) may be divided between identification information(which may be hardcoded in the second IC 900 using laser-blown fuses),information in the memory 932 (which may include open state and closedstate information), and error code (which may be calculated using astandard algorithm). The error code may be generated every time a readoperation is performed because the information stored in the memory 922may have changed since the most recent read operation. In someembodiments, the entire memory 922 is read and serially transported tothe first IC 800, where the data are encoded and modulated fortransmission to the reader.

The main controller 830 is in the first IC 800. The control bus (notshown; e.g., between the first and second ICs 800 and 900, or in thecontinuity state sensing system) encodes the state of the maincontroller 830 in the first IC 800, the state of any error flags, andthe state of the auxiliary controller 910 in the second IC 900. Thefirst IC 800 and the second IC 900 are synchronized using this bus sothat each IC is in the correct state during operation.

On system start-up, the second IC 900 initializes a memory addresscounter (e.g., in the read circuits 932) to a start bit (e.g., a firstaddressed bit in the memory 922), writes to a start flag location, andmoves the memory address counter to the next location (address) in thememory 922. Every time an open state is detected, a corresponding bit inthe memory 922 is written, and the address counter (e.g., an “openstate” address counter) is incremented. The “open state” address countermay also be incremented at the end of a predetermined time period (e.g.,every hour, every 8 hours, every day, etc.). without writing to acorresponding memory bit. The portion of the memory and an addresscounter corresponding to closed state detection can operate similarly oridentically. This allows the system to keep a record of open state andclosed state detections (and, optionally, the time and/or time periodsin which such detections were made). in some embodiments, the presentcontinuity state sensing system may record a maximum number of openand/or closed states, or a maximum length of time of operation, in whichcase it sets an “end-of-life” flag and writes to the memory locationcorresponding to the flag.

The memory write circuits 924 may use the battery voltage to pump up thevoltage to a “Battery++” level. In other words, if the battery voltageis ×V, then the “Battery++” voltage is >×V (e.g., ≥1.2×, ≥1.3×, ≥1.5×,etc.). When the memory comprises nonvolatile cells (e.g., one-timeprogrammable cells, EPROM cells, etc.), a voltage greater than thebattery voltage may be needed to write to the cell.

In some embodiments, the memory 922 comprises a non-volatile memoryarray that, along with programming circuits in the write module 924,allows storage of information at a level or resolution of a single bit.The memory 922 may be used to store time stamps of open/closed statedetection events, as well as the data itself. In one embodiment, thememory 922 stores usage data (e.g., the number of sequential openstate-closed state detection events), along with error flags (e.g., a“partially open” or “partially closed” state, preceded and followed bythe same continuity state) and other information that can be analyzed(e.g., by software) to determine compliance with product usageinstructions.

For the write operation to nonvolatile memory to occur successfully, avoltage higher than the battery voltage is generated using a charge pump(e.g., charge pump 1110 in the exemplary nonvolatile memory programmingcircuitry 1100 in FIG. 16). The charge pump 1110 may include switchescontrolled by a clock signal (e.g., CPCLK) to transfer charge (e.g.,VBATT) from the battery (not shown) to a storage capacitor 1115 thatdevelops the write voltage across its terminals. Upon receiving a writerequest (e.g., in the main controller 830), a voltage is applied toprogram a nonvolatile memory (e.g., OTP) cells 1130 a-n. In someembodiments, programming comprises applying a voltage sufficiently highto break down a dielectric layer in the memory cell. Meanwhile, thestorage capacitor rebuilds charge and is ready to transfer it into thenext memory cell when a write request for that cell is provided (e.g.,to the main controller 830).

The control circuits for programming and/or writing to the nonvolatilememory 1130 a-n are shown in FIG. 16. These circuits include the chargepump 1110, the storage capacitor 1115, and a control circuit 1120. Thenonvolatile memory 1130 a-n includes n individual nonvolatile memorycells, where n is an integer of at least 4 (e.g., 2×, where x is aninteger of at least 3), and each cell stores one bit of data. Thenonvolatile memory 1130 a-n may be a single row or column of cells, oran array of 2 or more rows and 2 or more columns. The individualnonvolatile memory cells may be accessed by corresponding addresssignals.

In some embodiments, the frequency of the clock signal (e.g., CPCLK) maybe varied with differing values of the storage capacitor. As a result,the voltage to program or write into a nonvolatile memory cell 1130 a-nmay be programmable as well. The circuitry associated with programmingthe nonvolatile memory cells 1130 a-n may be active or turned on onlyfor the duration of a read or write/program operation, during which timean enable signal may be provided to the circuit block 1100. Powerconsumption from the battery may therefore be limited to the timeinterval when the enable signal is active.

An exemplary charge pump 1110 is shown in detail in FIG. 17. The chargepump 1110 is configured to increase the voltage from the battery to alevel sufficient to enable the write operation (e.g., program thenonvolatile memory cells 1130 a-n in FIG. 16). The charge pump 1110 usesswitches mn1-8 and mp1-8, controlled by a clock signal (e.g., CLK andits complement, CLKB) to transfer charge from the battery (VBATT in FIG.16, VDD in FIG. 17) to a storage capacitor Cout. Upon receiving aninstruction to program one or more nonvolatile memory cells 1130 a-n,the charge stored on the capacitor Cout is transferred to thenonvolatile memory cell(s), and the voltage necessary to program thecell(s) (e.g., by breaking down a thin dielectric layer in the cell) isapplied to the cell(s). The charge pump 1110 is configured to deliver aminimum programming voltage (e.g., at least 3V, 4V, 5V, etc., but >thebattery voltage or VDD) and/or a maximum or excess current (e.g., up to2 mA, 4 mA, 6 mA, etc.) for a short duration of time (e.g., 1-1000 ms,or any value or range of values therein). Upon delivery of theprogramming voltage, the impedance of the programmed memory cell 1130 issignificantly reduced. Measurement of the impedance may validate asuccessful programming operation. The PIC 900 (FIG. 12B) also containscontrol circuitry (not shown) configured to regulate the charge pumpvoltage at a desired or predetermined voltage for the duration of thewrite operation.

Alternatively, a Dickson charge pump (not shown) may be used instead ofthe charge pump 1110 in FIG. 17. The Dickson charge pump comprises aplurality of MOS switches (e.g., NMOS transistors connected in seriesbetween source/drain terminal of adjacent switches, the first of whichis connected as a diode such that the input voltage is received at botha source/drain terminal and the gate), controlled by different phases ofa clock signal (e.g., that are 180° apart). The clock signal may beprovided by a clock generator that is external to the second IC 900. Thecharge is transferred from one switch to the next and stored inintermediate “flying” capacitors (e.g., having one electrode receivingone phase of the clock signal and another electrode connected to thegate of a MOS switch), and finally into a storage capacitor thatprovides the programming voltage. The programming voltage in the Dicksoncharge pump depends on number of stages in the pump, the flyingcapacitors (e.g., the capacitances thereof), and the frequency of theclock.

In order to mitigate the potential impact of a breakdown voltage on theMOS switches in the Dickson charge pump, a modified Dickson charge pumpmay be used as shown in FIG. 17. The gate-source and gate-drain voltagesat the switches mn1-8 and mp1-8 are kept below the battery voltage VDD,even though the absolute voltage developed across each stage mayincrease by a factor of up to 2. However, the modified charge pumparchitecture shown in FIG. 17 may increase the number of capacitors C(each stage may include two capacitors C), thereby increasing the realestate consumed by the charge pump 1115.

The charge pump 1110 may also include a buffer (not shown) driving thegates of the MOS switches mn1-8 and mp1-8. In some embodiments, thebuffer may comprise a plurality of inverter stages connected in series(i.e., the output of a first inverter is an input to a second inverter)and a logic gate (e.g., a NAND or AND gate) at an input of the pluralityof inverter stages (e.g., receiving at least the clock signal CLK and anenable signal), where the plurality of inverter stages are configured tooutput the clock signal CLK and its complement CLKB. The buffers may besized so that they can operate at high frequency (e.g., >500 kHz, 900kHz, >13 MHz, etc.) and drive the gates of the MOS switches mn1-8 andmp1-8 close to the supply voltage VDD and ground to effectively transferthe charge across the switches. Any leakage in the capacitors C due toequivalent series resistance (ESR) may affect the output voltage Vout,and should be minimized to the extent possible under the circumstances.

Cyclic Redundancy Checking (CRC) is a technique for detecting (andoptionally correcting) errors in digital data that may be transmitted asa long string of serial digital data bits. For example, the CRC codeadded by the dynamic CRC circuit 934 (FIG. 12B) to the data from theread circuits 932 may comprise p bits (e.g., where p is an integer of atleast 2, such as 4, 8, 10, 16, etc.), attached to a serial payload of qbits (e.g., where q is an integer of at least 60, 120, 180, 240, etc.).The sum of p+q may conform to a known protocol for wireless transmissionof serial data (e.g., where [p+q]=64, 128, 192, 256, etc.). The dynamicCRC circuit 934 attaches the CRC code to the data string using astandard polynomial. The receiver (e.g., a smart phone; not shown)validates an error-free transmission by applying the same polynomial tothe received data and comparing the result to the received CRC code. Incase of a discrepancy (a logic 0 or a logic 1 was received in error),the comparison (e.g., a CRC check) will fail, and the receiver willdiscard the incorrect data.

In a further embodiment, the continuity sensor may comprise the system800′ shown in FIG. 18. The system 800′ comprises an external MCU 830′that functions as the main controller (e.g., 830 in FIG. 12A), thepresent open state-closed state sensor 400/810/820, a battery 835 andpower management functionality. The power management functionalitycomprises a conventional power-on switch 836 that reduces or minimizesbattery drain while the sensor is not in use. In a further embodiment,the power-on switch 836 can also electrically disconnect (e.g., turnoff) the battery supply to the circuitry in the system 800′. At leastone of the circuits (e.g., the MCU 830′) is configured to transmitsignals in accordance with a wireless protocol (e.g., to read and/orreport the time at which the package or container is opened). The MCU830′ and the IC comprising the present open state and closed statedetectors 810 and 820 are in different clock domains during operation.In at least one embodiment, the low power oscillator 840′ that providesone or more timing signals to the MCU 830′ may comprise an externalresistor 847 and an external capacitor 849. The components having anidentification number identical to a component in another Figure operateidentically or substantially identically to the component in the otherFigure (as described herein).

FIG. 19 shows another exemplary integrated circuit 1200 for use in thepresent device. Some or all of the circuit and/or functional blocks inthe exemplary integrated circuit 1200 can be present in the integratedcircuit in any embodiment of the present invention. Additional circuitblocks, such as one or more display drivers, can also be included incertain embodiments.

The exemplary integrated circuit (IC) 1200 for use with the presentsecurity device includes one or more sensors (e.g., the presentcontinuity sensor) 1210, a threshold comparator 1220 receivinginformation (e.g., a signal) from the sensor(s) 1210, a pulse driver1240 receiving an output of the threshold comparator 1220, a memory 1260storing sensor data from the pulse driver 1240, one or more bit lines(BL) 1272 for reading data from the memory 1260, one or more senseamplifiers (SA) 1274 for converting the signal(s) on the bit line(s) todigital signals, one or more latches 1276 for temporarily storing datafrom the sense amplifier(s), and a transmitter (e.g., modulator) 1290configured to output data (including an identification code) from thedevice. The exemplary IC 1200 in FIG. 12 also contains a clock (e.g.,oscillator) 1250 configured to provide a timing signal (e.g., CLK) thatcontrols the timing of certain operations in the IC 1200 and a memorytiming control block or circuit 1270 that controls the timing of memoryread operations. The modulator 1290 also receives the timing signal(CLK) from the clock circuit or a slowed-down or sped-up variationthereof. The exemplary IC 1200 may also include a power supply block orcircuit 1280 that provides a direct current (e.g., VCC) to variouscircuits and/or circuit blocks in the IC. The memory 1260 may alsocontain identification code. The portion of the memory 1260 containingidentification code may be printed. The IC 1200 may further contain areceiver (e.g., a demodulator), one or more rectifiers (e.g., arectifying diode, one or more half-bridge or full-bridge rectifiers,etc.), one or more tuning or storage capacitors, etc. Terminals in themodulator 1290 and the power supply 1280 may be connected to ends of anantenna (e.g., at Coil1 and Coil2). The antenna may be a stationary(e.g., the second or third) coil, as described herein. In oneembodiment, the IC 1200 further comprises one or more display drivers,and the battery 1230 and/or the power supply 1280 may be connected toone or more leads providing power to the display driver(s) andoptionally a ground plane or other ground potential.

The memory in a wireless (e.g., an NFC or RF) security device maycontain a fixed number of bits. In some implementations, an NFC tag maycontain 128 or 256 bits. Some bits are allocated to overhead(non-payload) data for format identification and data integrity (CRC)checking. The payload of the wireless device consumes the remainder ofthe bits. For example, the payload can be up to 96 bits in the case ofthe 128-bit NFC tag and up to 224 bits in the case of the 256-bit NFCtag.

The payload of the NFC device can be allocated to variable amounts offixed ROM bits (which are generally—but not always—used as a uniqueidentification number). When print methods are used in manufacturing theNFC device, the ROM bits are permanently encoded and cannot beelectrically modified. Any payload bits that are not allocated as fixedROM bits can be allocated as dynamic sensor bits (e.g., for thecontinuity sensor). These sensor bits can change values, based on asensed input. Different splits or allocations between ROM and sensorbits are indicated by data format bits that are part of the non-payloador ‘overhead’ bits, generally in the first 16 bits of the NFC tagmemory.

One example of how continuity sensing may be implemented in the presentinvention involves a sensor 1210 that detects the voltage on astationary coil, as described herein. The detected voltage is comparedto a threshold voltage in the threshold comparator 1220, which outputs adigital or analog value corresponding to a continuity state of thepackage or container, and the pulse driver 1240 stores the value in thememory 1260. In a relatively simple example, when the voltage detectedon the first stationary coil is equal to or greater than the thresholdvoltage of the “closed state” sensor, the package or container isclosed, and when the voltage detected on the second stationary coil isequal to or greater than the threshold voltage of the “open state”sensor, the package or container is open. When the voltages detected onboth stationary coils are less than the corresponding thresholdvoltages, the package or container is partially closed or partiallyopen. Thus, one or more continuity state bits in the memory 1260 store astate that reflects the detected voltage(s). This indicates to thereader (e.g., an NFC smartphone, etc.) that the protected container isclosed, open, or somewhere in-between. The ROM ID bits do not change,but any data integrity bits (e.g., for CRC) may be updated to reflectthe continuity state of the package or container.

The IC 1200 in the present device may include one or more other sensorsin addition to the continuity sensor(s). For example, the IC 1200 canfurther include one or more temperature sensors, humidity sensors,electromagnetic field sensors, current/voltage/power sensors, lightsensors, and/or chemical sensors (e.g., for oxygen, carbon monoxide,carbon dioxide, nitrogen oxides, sulfur dioxide and/or trioxide, ozone,one or more toxins, etc.). The present IC may also include one or moretime sensors (e.g., configured to count or determine elapsed time),which may include the clock circuit (which can be a basis for areal-time clock) 1250 and one or more counters, dividers, etc., as isknown in the art. Such sensors may be on the same substrate as theantenna (e.g., one of the stationary coils), the battery 1250 and/or theIC 1200, or on a different substrate that is electrically connectable tothe battery 1250 and the IC 1200.

Each of the embodiments of the invention described with reference to theFigures may be modified by the disclosures connected to the otherembodiments and/or by the other disclosures herein, including in the‘Summary of the Invention’ section and the claims.

The foregoing descriptions of specific embodiments of the presentinvention have been presented for purposes of illustration anddescription. They are not intended to be exhaustive or to limit theinvention to the precise forms disclosed, and obviously manymodifications and variations are possible in light of the aboveteaching. The embodiments were chosen and described in order to bestexplain the principles of the invention and its practical application,to thereby enable others skilled in the art to best utilize theinvention and various embodiments with various modifications as aresuited to the particular use contemplated. It is intended that the scopeof the invention be defined by the Claims appended hereto and theirequivalents.

The invention claimed is:
 1. A multi-state article which comprises asensor for sensing when the article is in at least a first one of itsstates, the sensor comprising a system of coils which is adapted toprovide a coil coupling which is representative of the first state whenthe article is in the first state; wherein the article comprises a firststructure, which is provided with at least one coil of the coil systemof the sensor, and a second structure, which is provided with the restof the coils of the coil system of the sensor, and the first and secondstructures are movable relative to one another to move the articlebetween its first state and a second state and to change the position ofthe least one coil relative to the rest of the coils to change thecoupling in the coil system thereby to sense when the article is in itsfirst state, and; wherein the at least one coil comprise a bridging coiland the rest of the coils comprise a driver coil and a detector coil andwherein in the first state of the article the driver coil is able tocouple with the detector coil through the bridging coil to provide acoupling with the detector coil which is representative of the firststate.
 2. The article of claim 1, wherein the article comprises aprescribed usage regime and wherein the sensor comprises an adherencesensor for sensing article use events and storing a use event history,the sensor comprising a NFC antenna for wireless transfer of the usehistory.
 3. The article of claim 2, wherein the NFC antenna enableswireless communication between the sensor and another NFC-enabledarticle of sensor data concerning the use event history.
 4. The articleof claim 1, wherein the sensor is an electronic sensor of which at leastthe coil system is printed.
 5. The article of claim 1, wherein in thesecond state the bridging coil couples with the driver coil to provide acoupling which is representative of the second state of the article. 6.The article of claim 1, wherein the driver coil is a NFC antenna.
 7. Thearticle of claim 1, wherein the sensor is an electronic device whichcomprises a memory to store sensor data representative of the statessensed.
 8. The article of claim 7, wherein the sensor is adapted tostore in memory time data associated with the state data.
 9. The articleof claim 1, wherein the article has open and closed states as its firstand second states.
 10. The article of claim 1, wherein the article ismanually operable to effect its change of state.
 11. The article ofclaim 1, which is a multi-use, multi-state article.
 12. The article ofclaim 11, wherein the article contains or is adapted to contain a supplyof substance which is to be dispensed or made available for dispensingover the course of a number of uses until the supply is empty or isdeemed empty.
 13. The article of claim 1, wherein the article is aninhaler.
 14. The article of claim 1, wherein the sensor includes asignal generator adapted to produce a signal when the article is in saidfirst state which is representative of the article being in the firststate, and wherein the signal generator is a coil in the system ofcoils, wherein the coil comprises an NFC antenna.
 15. A multi-statearticle which comprises a sensor for sensing when the article is in atleast a first one of its states, the sensor comprising a system of coilswhich is adapted to provide a coil coupling which is representative ofthe first state when the article is in the first state; wherein thearticle contains or is adapted to contain a supply of substance which isto be dispensed or made available for dispensing over the course of anumber of uses until the supply is empty or is deemed empty; and whereinthe article is an inhaler.
 16. The article of claim 15, which is furtheradapted to provide a coil coupling which is representative of a secondstate, different from the first state, of the article when the articleis in the second state.
 17. The article of claim 15, wherein the coilsare adapted to adopt different coil configurations including a firstcoil configuration which is adopted when the article is in the firststate and which is able to provide the coil coupling which isrepresentative of the first state.
 18. The article of claim 17, whereinthe coil system further has a second coil configuration which is adoptedwhen the article is in a second state, different from the first state,of the article and which is able to provide a coil coupling which isrepresentative of the second state.
 19. The article of claim 18, whereinmovement of the article between its first and second states causes thecoil system configuration to move to the coil configuration whichcorresponds to the respective article state.
 20. The article of claim15, wherein the sensor comprises a near-field communication (NFC)antenna.
 21. The article of claim 20, wherein the sensor includes asignal generator adapted to produce a signal when the article is in saidfirst state which is representative of the article being in the firststate, and wherein the signal generator is a coil in the system ofcoils, wherein the coil comprises the NFC antenna.
 22. The article ofclaim 15, wherein the sensor includes a movable first coil which moveswith respect to at least one other coil as the article moves between itsdifferent states.
 23. The article of claim 22, wherein the movable firstcoil is movable between first and second positions, the first of whichis the position of the movable first coil in the first state of thearticle.
 24. The article of claim 23, wherein the sensor has second andthird coils and in the first position the movable first coil is disposedadjacent to the second coil for a coupling therewith representative ofthe article being in the first state.
 25. The article of claim 24,wherein in its second position the movable first coil is disposedadjacent the third coil for a second coupling therewith which isrepresentative of the article being in a second state.
 26. The articleof claim 15, wherein the article comprises a first structure, which isprovided with at least one coil of the coil system of the sensor, and asecond structure, which is provided with the rest of the coils of thecoil system of the sensor, and the first and second structures aremovable relative to one another to move the article between its firststate and a second state and to change the position of the least onecoil relative to the rest of the coils to change the coupling in thecoil system thereby to sense when the article is in its first state and,optionally, its second state.
 27. The article of claim 15, wherein theinhaler is a multi-dose dry powder inhaler.
 28. The article of claim 15,wherein the article has an open-use-close operating sequence.
 29. Thearticle of 28, wherein the article has an outlet and a closure thereforand the article is moved between closed and open states by moving theclosure from a closed position, in which it closes the outlet, to anopen position, in which the outlet is opened.
 30. The article of claim29, wherein the closure is a mouthpiece cover and actuator of theinhaler.
 31. The article of claim 15, wherein the article comprises aprescribed usage regime and wherein the sensor comprises an adherencesensor for sensing article use events and storing a use event history,the sensor comprising a NFC antenna for wireless transfer of the usehistory.
 32. The article of claim 31, wherein the NFC antenna enableswireless communication between the sensor and another NFC-enabledarticle of sensor data concerning the use event history.
 33. The articleof claim 15, wherein the sensor is an electronic sensor of which atleast the coil system is printed.
 34. The article of claim 15, whereinthe sensor is an electronic device which comprises a memory to storesensor data representative of the states sensed.
 35. The article ofclaim 34, wherein the sensor is adapted to store in memory time dataassociated with the state data.
 36. The article of claim 15, wherein thearticle has a second state, and said article is open and capable ofdispensing substance in its first state and closed and incapable fordispensing substance in its second state.
 37. The article of claim 15,wherein the article is manually operable to effect its change of state.